PURPOSE OF REVIEW Leptin, a key hormone in energy homeostasis and neuroendocrine function, has a permissive role in initiating puberty and is crucial in the pathogenesis of reproductive dysfunction in several disease states of energy imbalance. KiSS1 neurons have recently been suggested to mediate leptin's effect on the reproductive system. New insights from recent animal studies and clinical t...

Reproductive dysfunctions are common and wide-ranging in women with epilepsy. Menstrual cycle disruption, anovulatory cycles, disturbances in hypothalamic and/or pituitary hormones, and disturbances in gonadal steroids are more common among women with epilepsy. Sexual dysfunction can present as either disorders of desire or physiologic arousal, but the most common dysfunction appears to be an i...

Polycystic Ovarian Syndrome (PCOS) is endocrine and gynecological disorder that affects women of reproductive age. This a case report patient with PCOS who was misdiagnosed presented several symptoms. emphasizes the need for holistic healthcare approach to treat underlying organ dysfunction in PCOS. It highlights interconnectedness between dysfunction. examines chronic inflammatory state, risk ...

Mitochondrial dysfunction has been proposed to play a pivotal role in neurodegenerative diseases, including Alzheimer's disease (AD). To address whether mitochondrial dysfunction precedes the development of AD pathology, we conducted mitochondrial functional analyses in female triple transgenic Alzheimer's mice (3xTg-AD) and age-matched nontransgenic (nonTg). Mitochondrial dysfunction in the 3x...

PURPOSE/OBJECTIVES To describe the cognitive dysfunction experienced by two women after they received adjuvant chemotherapy for breast cancer and to discuss the potential role of changes in reproductive status and depression in the development of cognitive dysfunction. DATA SOURCES Journal articles, research data, and clinical experience. DATA SYNTHESIS Following chemotherapy, 17%-50% of wo...