Cerebral vessels of the spontaneously hypertensive rat (SHR) are less susceptible to disruption of the blood-brain barrier to proteins during acute hypertension than normotensive controls. This protective adaptation in SHR during acute hypertension is thought to be due to cerebral vascular hypertrophy which leads to increased vascular resistance and attenuation of the increase in cerebral blood...

To evaluate the mechanism of chronic thiazide diuretic action in hypertension, we treated 19 essential hypertensive white men for 1-month periods on placebo alone and hydrochlorothiazide alone. During therapy, mean arterial pressure (MAP) fell, but radioisotopically determined intravascular volume remained unchanged, suggesting other mechanisms of thiazide action upon blood pressure. In the ren...

A functional aspect of the vascular system is defined as physiology, which covers mostly cardiovascular, cerebrovascular, renovascular and pulmonary systems. Most functions with perfect homeostasis under coverage haemodynamics. This haemodynamics maintains a steady relationship between intravascular pressure (P), overall resistance (R) circulatory flow (F). To explore more unknown facts physiol...

Introduction: Renovascular hypertension is among the significant causes of severe in pediatrics. Primary therapeutic approaches, including drug therapy or angioplasty, are not always feasible, and their effectiveness variable. Meanwhile, several conditions leading to renal function impairment, artery stenosis, may represent respective kidney as an apparently non-functioning organ various imagin...

Renovascular hypertension is a potentially curable form of high blood pressure that is thought to be extremely rare among blacks. We demonstrate, however, that in a clinically selected population, the prevalence of renovascular hypertension is similar in blacks and whites. We prospectively evaluated 167 hypertensive subjects who had one or more clinical features known to be associated with reno...

Twenty-three patients were evaluated from 1-15 (mean 6) years after recovering from an episode of diarrhea-associated associated childhood hemolytic uremic syndrome (DA-HUS). All patients had received only conservative treatment; none had been given experimental, anti-coagulant, or immunological therapies. Follow-up studies included morphologic and duplex Doppler sonograms. Doppler sonography w...

Male Sprague-Dawley rats (200-250 g) were fed low protein (6%) diets (LP rats), high protein (50%) diets (HP rats), or regular rat chow (approximately 16% protein) (control rats) and studied under anesthesia after 2 weeks. Dietary protein intake did not affect mean arterial pressure, but renal blood flow was increased in the HP rats and decreased in the LP rats compared with the control rats. M...

Renovascular disease includes renal artery stenosis, renovascular hypertension, and azotemic renovascular disease (ischemic nephropathy). It is important to distinguish between renovascular hypertension and renal artery stenosis. Stenosis of the renal artery is common in nonhypertensive elderly persons and is an associated but noncausative finding in a number of hypertensive patients. Renovascu...

Hindquarter peripheral resistance, calculated as arterial pressure divided by hindquarter blood flow, decreased significantly on ganglionic blockade with hexamethonium bromide in four kinds of experimentally hypertensive rats, i.e. spontaneously hypertensive rats (SHR), DOCA-salt hypertensive rats, and one-kidney, one-clip and two-kidney, one-clip renovascular hypertensive rats, but not in norm...

Renovascular hypertension is a potentially curable form of high blood pressure. However, it is unclear how best to select patients who are likely to have renovascular hypertension, what diagnostic strategy to use in these selected patients, and how to predict the hemodynamic significance of a renal artery stenosis. We determined the prevalence of renovascular hypertension in adults who exhibite...