BACKGROUND AND OBJECTIVES The main objectives of the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial were to evaluate the role of antimicrobial prophylaxis in the prevention of recurrent urinary tract infection (UTI) and renal scarring in children with vesicoureteral reflux (VUR). We present a comprehensive evaluation of renal scarring outcomes in RIVUR trial parti...

PURPOSE Intrarenal reflux (IRR) occurs in 3-10% of cases of total reflux and can lead to renal injury, which may eventually result in renal scarring. In this study, we evaluated the clinical importance of IRR detected by voiding cystourethrography and evaluated the relationship between IRR and renal scarring. MATERIALS AND METHODS From January 2002 to May 2008, 50 patients who were diagnosed ...

BACKGROUND The deletion (D) polymorphism of the gene encoding angiotensin-I converting enzyme has been implicated as a risk factor for progressive renal disease in several conditions. This study was designed to evaluate the association between homozygosity for the D allele and susceptibility to renal scarring in children with vesico-ureteric reflux (VUR). METHODS Two-hundred-and-six children ...

OBJECTIVE To evaluate the role of vitamin A on renal scarring in recurrent urinary tract infections (UTIs). DESIGN Twenty three children with UTIs and renal scarring (mean (SD) age 7.3 (3.9) years) and 91 children without renal scarring (6.4 (3.4) years) were studied. All the children had serum vitamin A and beta-carotene measurements and nutritional evaluation. Renal scarring was assessed by...

Objective—To evaluate the role of vitamin A on renal scarring in recurrent urinary tract infections (UTIs). Design—Twenty three children with UTIs and renal scarring (mean (SD) age 7.3 (3.9) years) and 91 children without renal scarring (6.4 (3.4) years) were studied. All the children had serum vitamin A and â-carotene measurements and nutritional evaluation. Renal scarring was assessed by tech...

Introduction: Renal scarring, which can be detected by DMSA renal scan, has been demonstrated to cause hypertension, proteinuria and chronic kidney disease (CKD). We reviewed the proportion of risk factors outcomes among children who were referred for scan in a tertiary teaching hospital. Methods: All records less than 18 years old underwent over ten-year period, reviewed. Among whose cortical ...

IMPORTANCE No studies have systematically examined the accuracy of clinical, laboratory, and imaging variables in detecting renal scarring in children and adolescents with a first urinary tract infection. OBJECTIVES To identify independent prognostic factors for the development of renal scarring and to combine these factors in prediction models that could be useful in clinical practice. DAT...

BACKGROUND Acute pyelonephritis often leaves children with permanent renal scarring. AIMS To compare the prevalence of scarring following initial treatment with antibiotics administered intravenously for 10 or three days. METHODS In a prospective two centre trial, 220 patients aged 3 months to 16 years with positive urine culture and acute renal lesions on initial DMSA scintigraphy, were ra...