background: corn silk (cs) is widely used in iranian traditional medicine and feijoa sellowiana(fs) is a native plant widespread in the southern parts of iran. the aim of the present study was to assess renal protective activities of cs and fs against dosage induced injury by ecstasy (mdma) using insitu rat renal perfusion (irrp) system.methods: hydro-alcoholic extract of cs and fs (10, 20, 40 ...

objective(s):bradykinin is a part of the kinin-kallikreinsystem which is involved in ischemia-reperfusion injury via b1 and b2 receptors.noscapine is a non-competitive antagonist of bradykinin receptors. noscapine has been reported to to be able to protect some organs against ischemia-reperfusion injury but its effect on renal ischemia-reperfusion injury (rir) in rats is unknown. therefore, the...

introduction: this study was designed to evaluate the effects of treatment with flaxseed oil (fso) on renal ischemia-reperfusion (rir) injuries in rats. materials and methods: in this study, 32 wistar rats were randomly studied in four groups: co+ns (control group with normal saline administration), sh+ns (sham group with normal saline administration), rir+ns and rir+fso. fso (0.2 ml) was admin...

background and aims: methotrexate (mtx), a folic acid antagonist, is widely used as a treatment for malignancies as well as in the treatment of various inflammatory and autoimmune disorders. nephrotoxicity is an important side-effect of this drug. prevention and treatment of mtx-induced renal dysfunction are essential to prevent potentially life-threatening mtx-associated toxicities, present st...

background: renal ischemia reperfusion (ir), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. the aim of this study was to investigate the effects of hydroxytyrosol (ht) on renal ischemia-reperfusion injury in mice. methods: male mice were randomly assigned to three groups (n = 9): (1) sham operated, (2...

background considering the significant geographical and ethnical differences in pattern of incidence, etiology and outcome of chronic kidney disease (ckd), the present study aimed to assess the etiology and outcome of ckd in iranian children. materials and methods in a cross-sectional study etiology and outcome of 372 children aged 3 months to 18 years with ckd was studied during the period 199...

conclusions treatment with epo and mel had a beneficial effect on renal ir injury. the results may also indicate that mel protects against morphological damage better than epo in renal ir injury. results ischemia-reperfusion significantly decreased the observed hb and hct values. the histopathological findings in the ir group confirmed that there was an increase in the hyaline cast and thickeni...

our study evaluated the differences between early and late hemodialysis (hd) initiation in the intensive care unit (icu) according to the rifle (risk, injury, failure, loss, and end-stage renal failure) and akin (acute kidney injury network) classifications. on the assumption that early initiation of hd in critical patients according to the rifle and akin criteria decreases mortality, we retros...

results a significant decrease in apoptotic cells and increase in proliferative reaction were observed in the i/r + hbo group compared to the i/r group. conclusions we demonstrated that hbo suppressed apoptosis, which caused inflammation after renal i/r, and promoted tubular cell regeneration. hbo has protective effects against aki caused by renal i/r through the inhibition of apoptosis. materi...