cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

Background: Renal cancer is one of the most common malignant tumors urinary system, with distant metastasis occurring 30% patients. Therefore, early detection and monitoring tumor progression are great significance in diagnosis treatment renal cancer. However, current biomarkers used to diagnose, monitor recurrence assess prognosis still uncertain. Circulating cells (CTCs) detached from primary...

Inherited forms of renal cancer are estimated to account for 2%–5% of all kidney cancer (1). Currently, 10 inherited cancer susceptibility syndromes are definitively associated with an increased risk of renal cancer (Table 1) and are described in more detail below. Patients with these inherited syndromes develop kidney cancer at an earlier age; furthermore, the lesions can be multifocal, bilate...

Aims: Renal vascular clamping during partial nephrectomy can lead to renal ischemia and kidney damage due to reperfusion injuries, but a surgical technique without any ischemia can eliminate such unwanted effects on kidney function. The present study aimed to demonstrate the feasibility of partial nephrectomy in conditions where the renal artery is ready to be clamped. Patient Information: In ...

BACKGROUND Metastatic renal cancers are relatively common. Most are metastases to the renal parenchyma via a hematogenous route and are derived from lung, breast, and gastrointestinal cancer, malignant melanoma, and hematologic malignant cancer. However, little is known about renal capsule metastasis from other cancers. CASE PRESENTATION We report a 71-year-old woman with breast cancer who wa...

68Ga Prostate-specific membrane antigen (PSMA) is an increasingly popular radiopharmaceutical tracer in prostate cancer and is becoming increasingly researched in other cancers such as breast cancer, renal cell carcinoma, glioblastoma multiforme, among others. Cholangiocarcinoma is the second most common primary hepatic malignant tumor; it is an aggressive tumor with a 5-year surviva...

Krüppel-like factor 4 (KLF4) is a transcription factor that can have divergent functions in different malignancies. The expression and role of KLF4 in renal cell cancer remain unclear. The purpose of this study is to determine epigenetic alterations and possible roles of KLF4 in renal cell carcinoma. The KLF4 expression in primary renal cell cancer tissues and case-matched normal renal tissues ...

The worry of potential residual renal cancer cells in donor kidney after resection of small renal cancer impedes the extensive use of such controversial donor source. To explore the impacts of organ preservation process on the survival of renal cancer cells, we detected cell proliferation and viability of benign and malignant renal cell lines and clinical renal samples after treated with simula...

Birt-Hogg-Dubé (BHD) syndrome is a cancer disorder caused by a pathogenic FLCN mutation characterized by fibrofolliculomas, lung cysts, pneumothorax, benign renal cyst, and renal cell carcinoma (RCC). In this case we describe a patient with bilateral renal tumour and a positive familial history for pneumothorax and renal cancer. Based on this clinical presentation, the patient was suspected for...