BACKGROUND Epilepsy is a common neurologic complication of tuberous sclerosis complex (TSC) and it is often refractory to treatment. Therefore, treating physicians are often reluctant to discontinue antiepileptic drugs (AEDs) in individuals with TSC who have attained seizure remission. To our knowledge, seizure remission and AED discontinuation in children with TSC has not been studied. OBJEC...

BACKGROUND It has been reported that thalidomide may be effective in treating inflammatory bowel disease (IBD). AIM To review the evidence examining the efficacy and safety of thalidomide for inducing and maintaining remission in Crohn's disease (CD) and ulcerative colitis (UC). METHODS The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed (1950-August 2014), EMBASE ...

OBJECTIVE To evaluate the analgesic effect of CT-guided microinvasive intervention on refractory carcinous pain. METHODS A total of 23 patients with poor response to drug therapy for carcinous pain were selected: 6 patients underwent CT-guided neurolytic celiac plexus block (NCPB), 5 patients underwent CT-guided(125)I implantation and 12 patients underwent combined CT-guided NCPB and CT-guide...

BACKGROUND To this date, only a small number of studies have described the long-term use of BTX in Hemifacial spasm. AIM To assess the prognosis and long-term effectiveness of Botulinum toxin A (BTXA) in the treatment of unilateral spasms of the eyelid. PATIENTS AND METHODS From September 1998 to January 2006, 245 consecutive cases of unilateral spasms of the eyelid were included in this re...

Objective. To evaluate the efficacy of infliximab (IFX) monotherapy versus infliximab-azathioprine sequential treatment in Crohn's disease (CD) patients. Methods. Patients newly diagnosed with CD using IFX as induction therapy were enrolled. After 6 times of IFX infusions, they were divided into IFX monotherapy group and IFX-AZA sequential therapy group. Clinical remission rates were assessed a...

Asthma is the most common chronic disease in children. The natural history of asthma is often characterized by periods of remission and relapse. The aim of this study was to determine the remission rate of asthmatic children after entering the second decade of life and remission related factors in a hospital-based cohort.The study population was asthmatic children who were diagnosed, registered...

OBJECTIVE Prediction of pathologic complete remission in breast cancer after preoperative therapy presents difficulties. We performed a meta-analysis to determine the ability of MRI to predict pathologic complete remission in patients with breast cancer after preoperative therapy. MATERIALS AND METHODS Medical subject heading terms ("MRI" and "Breast Neoplasm") and key words ("neoadjuvant" or...

introduction: arsenic trioxide is effective and approved for treatment of relapsed or refractory apl cases to atra but its effects in new cases of apl is not clear and needs long term follow up to dis close the role of this drug in treatment of apl in combination with chemotherapy/atra or alone. material and methods: we studied 111cases of apl (94 new case and 17 relapsed) diagnosed by mor phol...