OBJECTIVES To examine whether disrupted regulation of REM sleep propensity is implicated in nightmare (NM) pathophysiology. BACKGROUND Heightened REM propensity induced by REM sleep deprivation is belied by increases in REM %, REM density and the dream-like quality of dream mentation during post-deprivation recovery sleep. Compromised regulation of REM sleep propensity may be a contributing f...

Animal and human studies of sleep and learning have demonstrated that training on various tasks increases subsequent rapid eye movement (REM) sleep and phasic pontine-wave (P-wave) activity, followed by improvement in performance on the learned task. It is well documented that REM sleep deprivation after learning trials blocks the expected improvement in performance on subsequent retesting. Our...

STUDY OBJECTIVES The purpose of this study was to evaluate the effects of acute REM deprivation on daytime sleepiness/alertness, as measured by the MSLT. PARTICIPANTS Twenty-six healthy, normal volunteers (14 males and 12 females) participated in this study. Participating subjects were in good physical and psychological health and were asymptomatic as to sleep/wake complaints. INTERVENTIONS...

The present investigation attempted to replicate, in a cross-night design, the recent finding that early-night REM-sleep deprivation leads to more dreamlike late-night REM-sleep mentation. 8 5s were REM deprived on Night 1 and pseudodeprived on Night 3, while 8 5s were run in the reverse order. Reports of mental content were elicited from NREM and REM sleep on Nights 2 and 4. 5s and "watchers" ...

Two types of neurons are involved in the regulation of rapid eye movement (REM) sleep, the REM-ON and the REM-OFF neurons. As the name suggests, the REM-OFF neurons cease firing during REM sleep and they are norepinephrinergic. It has been shown that cessation of these neurons is a pre-requisite for the generation of REM sleep and GABA shuts them off. Further, if these neurons do not shut off, ...

BACKGROUND Rapid eye movement [REM] sleep deprivation is a stressor. It results in a predictable syndrome of physiological changes in rats. It has been proposed that reactive oxygen species and the resulting oxidative stress may be responsible for some of the effects of sleep deprivation. PURPOSE The present study was undertaken to investigate the reversible nature of the effects of 96 hours ...

In mammals and birds, sleep is associated with specific cortical electroencephalogram (EEG) patterns (Box 1), which may be divided into rapid eye movement (REM) and non-rapid eye movement (NREM) sleep [1]. The only known exceptions include the primitive egg-laying mammals echidnae [2], where a REM/NREM mixed state has been proposed. Some birds and marine mammals also have brief REM sleep and un...

Background and Aim: Tumor Necrose Factor-alpha (TNF-α) changes by REM sleep deprivation. Some believe that TNF-α is a biomarker in the deprivation of REM sleep. The patients with insomnia could be better after using Anti TNF-α or Infliximab (IFX), on the other hand, IFX effects on Patient Tolerance Threshold (PTT). Trying to manage the hospital inpatients’ pain is one of the common aims special...

acetylcholinesterase (ache) is a large glycoprotein that, aside from its known cholinolytic activity, co-exists with other transmitter systems and possesses other functions. in the present study, the effects of short-term rapid-eye-movement sleep deprivation (rem-sd) on ache activity in the anterior hypothalamic area have been investigated. using the flower-pot method, adult male albino rats we...

Intracellular signaling mechanisms within the pedunculopontine tegmental (PPT) nucleus for the regulation of recovery rapid eye movement (REM) sleep following REM sleep deprivation remain unknown. This study was designed to determine the role of PPT intracellular cAMP-dependent protein kinase A (cAMP-PKA) in the regulation of recovery REM sleep in freely moving rats. The results show that a bri...