This prospective study evaluated semiquantitative and qualitative catheter-culture methods for diagnosis of catheter-related infection (CRI) in newborns. Catheter tips from newborns admitted to the Neonatal Unit of the University Hospital of the Botucatu Medical School, UNESP were included in the study. Catheter cultures were performed with both semiquantitative and qualitative techniques. For ...

BACKGROUND A vaccine against human papillomavirus (HPV) types 6, 11, 16 and 18 is now licensed for use in Canada and many other countries. We sought to estimate the number needed to vaccinate to prevent HPV-related diseases and death. METHODS A cohort model of the natural history of HPV infection was developed. Model simulations were based on 209 different parameter sets that reproduced Canad...

INTRODUCTION Best clinical practice for patients with suspected catheter-related infection (CRI) remains unclear according to the latest Infectious Diseases Society of America (IDSA) guidelines. Thus, the objective of this study was to analyze clinical practice concerning the central venous catheter (CVC) and its impact on prognosis in patients with suspected CRI. METHODS We performed a prosp...

OBJECTIVE To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison. DESIGN Systematic review and mixed treatment comparison. SETTING Hospital and other healthcare settings. PARTICIPANTS Patients undergoing THR. PRIMARY AND SECONDARY OU...

The Strategic plan for measles and congenital rubella infection in the WHO European Region, was developed and implemented in 2002 and includes two objectives for 2010: interruption of indigenous measles transmission and the prevention of congenital rubella infection (CRI; less than one case of congenital rubella syndrome [CRS] per 100 000 live births). It has been recommended that the plan be r...

Epoprostenol (EPO) improves hemodynamics and survival in patients with advanced pulmonary arterial hypertension (PAH) by vessel dilatation and inhibiting platelet aggregation. 1 3 However, it requires continuous infusion and may lead to catheter-related complications (CRCs) (infection, thromboembolism, or bleeding). In patients with indwelling central venous catheters, the incidence of catheter...

Our objective in this study was to estimate the probability that a Chlamydia trachomatis (CT) infection will cause an episode of clinical pelvic inflammatory disease (PID) and the reduction in such episodes among women with CT that could be achieved by annual screening. We reappraised evidence from randomized controlled trials of screening and controlled observational studies that followed untr...

UNLABELLED Antimicrobial central venous catheters are discussed as a device to reduce catheter-related infections. Previously we have reported a study with 223 adult surgical patients randomized to receive either a rifampicin-miconazole-loaded central venous catheter (CVC) (n=118) or a standard CVC (n=105). The antimicrobial CVC was shown to reduce catheter colonization (CC) and catheter-relate...

OBJECTIVE To examine the association between injection cocaine use, hepatitis C virus (HCV) infection, and chronic renal impairment (CRI). DESIGN Prospective observational cohort study of HIV-HCV coinfected patients. METHODS Data from 1129 participants in the Canadian Co-Infection Cohort with baseline and follow-up serum creatinine measurements between 2003 and 2014 were analyzed. Prevalent...

BACKGROUND Intravenous prostanoid therapy is one cornerstone of therapy for patients with pre-capillary pulmonary hypertension (PH). Long-term central venous catheters expose patients to infectious complications. OBJECTIVES We report the incidence of catheter-related infection (CRI) and the spectrum of bacteria for ambulatory PH patients treated with iloprost via non-tunnelled central venous ...