Synonyms and related keywords: blood transfusions, blood products, acute hemolytic transfusion reactions, transfusion complications, blood product reactions, allergic transfusion reaction, blood type, circulatory volume overload, anaphylactic transfusion reaction, blood anaphylaxis, hemolytic reactions, allergic reactions, anaphylactic reaction, anaphylaxis, transfusion-related acute lung injur...

Background: Transfusion-Related Acute Lung Injury (TRALI) is a serious complication of blood transfusion. In recent years, TRALI has been reliably shown to be the most common cause of transfusion-related fatalities in the United States and in the United Kingdom. Its prevalence is about 1 in 1323 transfused components; however, it is often under diagnosed. Classically, TRALI present as noncardio...

BACKGROUND Transfusion-related acute lung injury (TRALI) is now the leading cause of transfusion-associated mortality, even though it is probably still underdiagnosed and underreported. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE ACTION The National Heart, Lung, and Blood Institute convened a working group to identify areas of research needed in TRALI. The working group identified the immediate...

To the Editor: Transfusion-related acute lung injury (TRALI) can be a serious complication resulting from the transfusion of plasma that contains antibodies against recipient white blood cells. There have been only four previously reported cases of recurrent TRALI [1–3]. We describe a patient with recurrent TRALI, emphasizing potential strategies to prevent this disease. A 25-year-old man with ...

Transfusion is an inevitable event in the life of many individuals. Transfusion medicine personnel attempt to provide blood products that will result in a safe and harmless transfusion. However, this is not always possible since no laboratory test gives totally accurate and reliable results all the time and testing in routine transfusion services is devoted primarily to the identification of re...

Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurrin...

Transfusion-related acute lung injury (TRALI) is an respiratory distress syndrome (ARDS) occurring during or within six hours after transfusion. On the other hand, while inhaled nitric oxide (iNO) temporarily improves arterial oxygenation with selective pulmonary vasodilation, there no evidence of mortality reduction in ARDS. We herein report a case which TRALI was diagnosed severe hypoxemia ca...

Transfusion of blood products can lead to various transfusion reactions. Transfusion reactions that can cause pulmonary complications are: circulatory overload, anaphylactic reactions, bacterial contamination and transfusion-related acute lung injury (TRALI). TRALI is a rare but life-threatening complication of transfusion. TRALI is now the leading cause of transfusion-related fatalities report...

Transfusion-related acute lung injury (TRALI) has emerged as one of the leading causes of transfusion-related morbidity and mortality and is undoubtedly under diagnosed. It is a serious pulmonary syndrome that can lead to death if not recognised and treated promptly. The diagnosis of TRALI is based primarily upon clinical signs and symptoms and is, in part, a diagnosis of exclusion.