Background and Purpose: Three mainstream strategies exist to detect the responses of regional cerebral blood flow to functional activation. We tested the significance of changes in raw regional cerebral blood flow data, regional cerebral blood flow data normalized by division by global cerebral blood flow (dependent model of the regional-to-global cerebral blood flow relation), and regional cer...

Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATP-sensitive potassium (KATP) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels. Methods: The change in cerebral blood flow was measured by a laser Doppler flowmeter in 18 Ne...

Using quantitative autoradiography, we studied sequential changes in regional cerebral blood flow during and after 2 minutes of bilateral common carotid artery occlusions in 18 gerbils. Occlusion (n = 4) led to severe ischemia in the forebrain (regional cerebral blood flow less than 5% of control [n = 4]) and midbrain (regional cerebral blood flow less than 10% of control), but was morphologica...

Can Plasma Skimming or Inconstancy of Regional Hematocrit Introduce Serious Errors in Regional Cerebral Blood Flow Measurements or Their Interpretation? • Recent reports indicate that in cases of elevated plasma or blood viscosity, red cell velocity through the cerebral microcirculation is unimpaired while plasma transit is retarded. One explanation may be that plasma skimming is increased, wit...

Several methods have been used to measure left ventricular regional blood flow in humans. However, limitations and lack of validation in patients are major problems. A continuous thermodilution technique to measure regional left ventricular blood flow in patients with coronary disease was validated in vivo. This technique permits simultaneous assessment of venous blood flow draining predominant...

Can Plasma Skimming or Inconstancy of Regional Hematocrit Introduce Serious Errors in Regional Cerebral Blood Flow Measurements or Their Interpretation? • Recent reports indicate that in cases of elevated plasma or blood viscosity, red cell velocity through the cerebral microcirculation is unimpaired while plasma transit is retarded. One explanation may be that plasma skimming is increased, wit...

background: the mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood.   objective: to investigate the role of nitric oxide (no) and atp-sensitive potassium (k atp ) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels.   methods: the change in cerebral blood flow was measured by a laser doppler flowmeter in...