Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we repo...

introduction: refractory status epilepticus is a life-threatening disease in children wherein seizure movements don't response to first line anti convulsion drugs. this study reviewed risk factors, management and early outcome of children with refractory status epilepticus. methods: patients with refractory status epilepticus admitted in tabriz children's hospital between 2003 and 200...

lamotrigine (ltg), a newly developed antiepileptic drug (aed), is efficacious in treating refractory epilepsy. this study was designed to evaluate the efficacy and safety of ltg as add-on therapy in 40 children with refractory epilepsy. the trial was an open-labeled prospective study in children with drug-resistant epilepsy aged <14 years, who had at least 4 seizures per month in spite of recei...

epilepsy is a neurological disease of the central nervous system. it is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. in the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

biotin is a water-soluble vitamin and co-factor for activation of carboxylases apoenzymes. biotinidase enzyme is essential for release of biotin from apoenzymes. absence of biotinidase is an autosomal recessive trait with a prevalence of 1 in 60000. clinical manifestations of biotinidase deficiency include dermatitis, alopecia, seizures, hypotonia, developmental delay, hearing loss, visual impa...

background: patients with gastroesophageal reflux disease (gerd) unresponsive to proton pump inhibitor (ppi) therapy are often labeled as having refractory gerd. one of the probable etiologies of refractory gerd is delayed gastric emptying. refractory gerd associated with gastroparesis is a complex condition with no definitive treatment to date. we opted, for the first time, to test the hypothe...

treatment of severe immune thrombocytopenic purpura (itp) accompanied by life-threatening bleeding events is challenging and a combination of treatment measures should be undertaken to rapidly increase the platelet count. herein, we report a case of severe itp in a seven-year-old boy who suffered from massive bleeding which was totally unresponsive to conventional therapeutic interventions. sin...

background: the induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. for patients with relapsed or refractory disease, alternative chemotherapy agents are available. monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozogami...

objective: the aim of this study was to evaluate the effect of premenstrual syndrome (pms) treatment with selective serotonin reuptake inhibitor (ssri) on treatment response of refractory hypertension of the patients. method: this was a triple-blind randomized clinical trial conducted on female patients suffering from refractory hypertension and pms at the same time. we obtained informed consen...

purpose: to determine the outcomes of visual correction with femto-lasik following pk. methods: in this prospective study, 34 eyes of 31 patient who had undergone thin – flap lasik due to high refractive error after corneal grafting were evaluated .after complete ocular examination and assessment of uncorrected and corrected distant visual acuity (ucva and bcva) , the patients underwent femto-l...