In order to determine the efficacy of recombinant hepatitis B vaccine in Iranian infants, we analyzed the efficacy of a recombinant hepatitis B vaccine in 115 infants aged 12-24 months born to HBsAg negative mothers who received three doses of HBV Antibody to hepatitis B surface antigen (anti-HBs) was checked after the third dose of the vaccine, 94.8% of the infants had developed protective...

brucellosis is a well-known infection in domestic animals which caused by brucella bacterium. due toserious economic and medical consequences of this disease, various efforts have been made to prevent theinfection through the use of recombinant vaccines based on brucella outer membrane protein (omp)antigens. the objectives of the present study were cloning, sequencing and epitope prediction of ...

introduction and aims: in order to prevent liver cirrhosis and hepatocellular carcinoma in later life, it is essential to prevent hepatitis b virus (hbv) infection in infants. despite the availability of an effective vaccine, hepatitis b still continues to be a significant health problem. the aim of this study is to reveal the efficacy of passive and active immunoprophylaxis for preventing peri...

background: enterotoxigenic escherichia coli (etec) strains are the major causes of diarrheal disease in humans and animals. colonization factors and enterotoxins are the major virulence factors in etec pathogenesis. for the broad-spectrum protection against etec, one could focus on colonization factors and non-toxic heat labile as a vaccine candidate. methods: a fusion protein is composed of a...

Background: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). Bacille Calmette-Guerin (BCG) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult TB vaccine. The aim of this study was to develop a new tuberculosis DNA vaccine candidate encoding a recombinant HspX-PPE44-EsxV fusion antigen of M. tuberculosis. Methods: ...

with the plasmid dna from a clinical isolate of enterotoxigenic escherichia coli (etec) h 10407 as template, pcr-mediated cloning of the sequence encoding the heat-labile toxin b subunit (l t -b) has been carried out. then this sequence was recloned into the ptrc 99a and pet23a expression vectors to give the pjasmids ptrcltb and petltb, respectively. after induction, the former plasmid provides...

background: the purity and correct folding of a recombinant protein is critical for any structural, biochemical and vaccine design studies. plasmodium vivax duffy binding protein-ii is a leading vaccine candidate for vivax malaria. in the present study, the purification process of recombinant dbp-ix (a variant form of pvdbp-ii) was optimized to achieve the highest yield and purity. moreover, na...

background   and   objectives:    the   toxin   co-regulated   pilus   a   (tcpa)   has   been   described   as   a   criti- cal  pathogenicity  factor  of   vibrio  cholerae .  tcpa  is  a  candidate  for  making  subunit  vaccine  against  chol- era.  the  aim  of  this  study  was  to  produce  a  candidate  vaccine  by  expressing  recombinant  tcpa  in   e.  coli . materials and methods: i...

vaccination of livestock with effective vaccine could be one of the control methods for hydatid cyst. in this study a new recombinant vaccine (eg95) from new zealand was prepared and used. thirty health sheep from the same race and identical age and sex were selected. there was no history of any past vaccination or disease in selected animals. animals were randomly categorized to four groups. o...