Sir, We read with interest the article recently published in Iranian Journal of Kidney Diseases, titled “Effect of Erythropoietin on Kidney Allograft Survival: Early Use After Transplantation” by Yassari and colleagues.1 This study focused on the impact of recombinant human erythropoietin on graft survival during the six months after kidney transplantation. In a univariable analysis, they concl...

Recombinant human erythropoietin is a glycoprotein hormone that stimulates erythropoiesis. In clonogenic assays of hematopoietic progenitors, high concen-trations of erythropoietin (Epo) increase CFU-E and diminish the number of granulocytes formed per culture plate. Fetal progenitors are more sensitive to these effects of Epo than progenitors from adults. We administered doses 50, 100, 200 IU/...

the pharmacokinetics of recombinant human erythropoietin (rhuepo) administered intravenously has been investigated in a group of five patients with chronic renal failure who were dialysis-dependent. the half-life of circulating erythropoietin decreased from 7.9±oa hr (mean ±so) at the beginning of treatment to 6.2±o.6 hr after 6 weeks and 5a±o.9 hr after 4 months of treatment. in spite of the s...

background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...

background: erythropoietin (epo) was first known as a factor for red blood cell proliferation and differentiation. new studies show the effects of epo on immune system. objective: in this study, the effects of pretreatment with recombinant human erythropoietin (rhuepo) on the anti-human leukocyte antibody (anti-hla) titer were determined. methods: three groups of rats were sensitized with human...

We compared the in vivo plasma clearance and organ accumulation in anesthetized rats of 125I-labeled, recombinant human erythropoietin and 125I-labeled, desialylated recombinant erythropoietin. The immediate volume of distribution of 125I-labeled, recombinant erythropoietin approximated that of the plasma volume. Its plasma clearance was multiexponential, with an initial rapid distribution phas...