Background: Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. New studies show the effects of EPO on immune system. Objective: In this study, the effects of pretreatment with recombinant human erythropoietin (rHuEPO) on the anti-human leukocyte antibody (anti-HLA) titer were determined. Methods: Three groups of rats were sensitized with human...

Background: Erythropoietin, as a principal hormone promotes red blood cell production in bone marrow. Varieties of erythropoietin biosimilar are being produced by recombinant DNA technology in cell cultures. The detection or quantification of these molecules are being performed by diff erent methods which some of theme such as Western blot and enzymelinked immunosorbent assay (ELISA) require sp...

background: erythropoietin (epo) was first known as a factor for red blood cell proliferation and differentiation. new studies show the effects of epo on immune system. objective: in this study, the effects of pretreatment with recombinant human erythropoietin (rhuepo) on the anti-human leukocyte antibody (anti-hla) titer were determined. methods: three groups of rats were sensitized with human...

Cardiovascular and renal diseases constitute two pathophysiological contexts of progressive fatal recognitions worldwide as priorities in terms health its entirety. Erythropoietin is a glycoprotein hormone which produces red blood cells, carry oxygen the blood. The objective was to know most prevalent modifiable risk factors found arterial hypertension, since this disease third cause death worl...

The Pichia pastoris expression system was used to produce recombinant human erythropoietin, a protein synthesized by the adult kidney and responsible for the regulation of red blood cell production. The entire recombinant human erythropoietin (rhEPO) gene was constructed using the Splicing by Overlap Extension by PCR (SOE-PCR) technique, cloned and expressed through the secretory pathway of the...

human erythropoietin causing pure red cell aplasia. Clin Nephrol 1997; 47: 331–335 8. Casadevall N, Nataf J, Viron B et al. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med 2002; 346: 469–475 9. Bunn HF. Drug-induced autoimmune red-cell aplasia [Letter]. N Engl J Med 2002; 346: 522–523 10. Weber G, Gross J, Kromminga A et ...

Approximately one third to one half of patients with cancer are anemic, a condition that diminishes the ability to engage in daily activities and undermines the overall quality of life. Although cancer-related anemia has many causes, one of the most important is inadequate production and impaired utilization of erythropoietin. At any given level of anemia, patients with cancer produce much less...

Background: Anemia is a common clinical problem in patients with chronic kidney disease and is associated with increased morbidity and mortality. Erythropoietin is a hormone synthesized in kidney responsible for red blood cell maturation in the bone marrow. It is deficient in majority of patients with advanced kidney disease predisposing to anemia. Therapeutic alternatives are recombinant human...

The definition blood doping was introduced by the media in the 1970s to describe the use of blood transfusion to increase red cell mass artificially, and in turn to enhance both maximal oxygen uptake and performance in endurance sports. Since the late 1980s blood doping is no longer achieved by autologous transfusion but instead through administration of recombinant human erythropoietin (rHuEpo).