نتایج جستجو برای: receptor activator for nuclear factor κb ligand
تعداد نتایج: 10973460 فیلتر نتایج به سال:
We investigated the effect of dietary zinc supplementation on bone metabolism in rats. Four-week-old male Wistar rats were fed a 30.0 mg zinc/kg diet (C), a 300.0 mg zinc/kg diet (HZ) or a 3,000.0 mg zinc/kg diet (EZ) for 4 weeks. The zinc content of the femur gradually increased in accordance with the gradual increase in the dietary zinc level. Although the mRNA expression of zinc transporters...
Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL) for their survival, proliferation, differentiation, and activation. The binding of RANKL to its receptor RANK triggers osteoclast precursors to differentiate into osteoclasts. This process depends on ...
Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality. The process is characterized by multiple steps: inflammation, fibrosis, and calcification. Numerous studies focalized on its physiopathology highlighting different "actors" for the multiple "acts." This paper focuses on the role of the tumor necrosis factor supe...
there has been considerable inconsistency regarding the potential relationship between dyslipidemia and bone metabolism. the inflammatory stimulation through the receptor activator of the nuclear factor kappa-b ligand (rankl)/ receptor activator of the nuclear factor kappa-b (rank)/ osteoprotegerin (opg) pathway could be the infrastructural mechanism for hypercholesterolemia-induced bone loss. ...
Aging cells not only cease growing, but also secrete various proteins such as inflammatory cytokines. This secretory phenomenon is known the senescence‑associated phenotype (SASP). The aim of present study was to elucidate effects senescence on differentiation osteoclast precursors (OCPs) and corresponding SASP. RAW264.7 were used OCPs cultured passage (P)5, P10 P20. Cell proliferation assays, ...
RATIONALE Vascular calcification is a process similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals in advanced atherosclerotic plaques. Monocyte-derived macrophages, located in atherosclerotic lesions and presenting heterogeneous phenotypes, from classical proinflammatory M1 to alternative anti-inflammatory M2 macrophages, could potentially display oste...
Abbreviations: adenovirus protein E1A, (AdV E1A); adult T-cell leukemia/lymphoma, (ATLL); calcium-sensing receptor, (CaR); cAMP-responsive element, (CRE); epidermal growth factor, (EGF)); extracellular matrix, (ECM); G-protein coupled receptors, (GPCR); human T lymphotropic virus type I, (HTLV-I); hypercalcaemia of malignancy, (HHM); interleukin-6, (IL-6); nuclear localization sequence, (NLS); ...
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