نتایج جستجو برای: reactive inhibition antibodies

تعداد نتایج: 615770  

Journal: :The Journal of Experimental Medicine 1985
J B Dale E H Beachey

We present evidence that a highly purified pepsin extract of type 5 streptococcal M protein (pep M5) contains at least three epitopes that are cross-reactive with sarcolemmal membrane proteins of human myocardium. The tissue-cross-reactive determinants of pep M5 are also partially shared with pep M6 and pep M19. Three rabbits immunized with a single 300 micrograms dose of pep M5 developed signi...

Journal: :Japanese journal of infectious diseases 2011
Eiji Konishi Mayu Konishi

Japanese encephalitis virus (JEV) and the four dengue viruses (DENV1-4) are co-distributed in Southeast and South Asia. Since JEV is antigenically cross-reactive with DENV1-4, the differentiation between these viruses using antibody assays may be difficult. Herein, we describe the development of an epitope-blocking enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody specific f...

Journal: :Infection and immunity 2001
K Brahimi E Badell J P Sauzet L BenMohamed P Daubersies C Guérin-Marchand G Snounou P Druilhe

The Plasmodium falciparum liver-stage antigen 3 (LSA3), a recently identified preerythrocytic antigen, induces protection against malaria in chimpanzees. Using antibodies from individuals with hyperimmunity to malaria affinity purified on recombinant or synthetic polypeptides of LSA3, we identified four non-cross-reactive B-cell epitopes in Plasmodium yoelii preerythrocytic stages. On sporozoit...

Journal: :Infection and immunity 1987
F Ota H Kato K Fukui

Two monoclonal antibodies against the cross-reactive antigens of S. cricetus (type a) and S. sobrinus (type d) were isolated. Galactose and especially melibiose inhibited the precipitin reaction markedly. Inhibition by melibiose was over 200-fold stronger than that by galactose. This may indicate that galactose-alpha 1, 6-glucose is the predominant antigenic determinant of this cross-reactive a...

Journal: :PLoS Pathogens 2009
Reiko Yoshida Manabu Igarashi Hiroichi Ozaki Noriko Kishida Daisuke Tomabechi Hiroshi Kida Kimihito Ito Ayato Takada

The hemagglutinin (HA) of influenza A viruses has been classified into sixteen distinct subtypes (H1-H16) to date. The HA subtypes of influenza A viruses are principally defined as serotypes determined by neutralization or hemagglutination inhibition tests using polyclonal antisera to the respective HA subtypes, which have little cross-reactivity to the other HA subtypes. Thus, it is generally ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1999
W Tang R A Stearns S M Bandiera Y Zhang C Raab M P Braun D C Dean J Pang K H Leung G A Doss J R Strauss G Y Kwei T H Rushmore S H Chiu T A Baillie

The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal hepatotoxicity that may be associated with the formation of reactive metabolites. In this study, three glutathione (GSH) adducts, namely 5-hydroxy-4-(glutathion-S-yl)diclofenac (M1), 4'-hydroxy-3'-(glutathion-S-yl)diclofenac (M2), and 5-hydroxy-6-(glutathion-S-yl)diclofenac (M3), were identified by liquid chr...

Journal: :The Journal of Experimental Medicine 1980
J B Dale I Ofek E H Beachey

The heterogeneity of a pepsin extract of type-24 M protein (pep M24) was demonstrated by absorption of type-specific and cross-reactive human antisera with M protein fragments and heterologous serotypes of M proteins, pepsin extract of type-5 M protein (pep M5) and pepsin extract of type-6 M protein (pep M6). 2 of 12 individuals immunized with pep M24 developed significant rises in antibody tit...

2011
Glendie Marcelin Rebecca DuBois Adam Rubrum Charles J. Russell Janet E. McElhaney Richard J. Webby

BACKGROUND Exposure to contemporary seasonal influenza A viruses affords partial immunity to pandemic H1N1 2009 influenza A virus (pH1N1) infection. The impact of antibodies to the neuraminidase (NA) of seasonal influenza A viruses to cross-immunity against pH1N1 infection is unknown. METHODS AND RESULTS Antibodies to the NA of different seasonal H1N1 influenza strains were tested for cross-r...

2011
Bindu Jayakrishnan David E. Hoke Christopher G. Langendorf Ashley M. Buckle Merrill J. Rowley

BACKGROUND Autoantibodies to GAD65 (anti-GAD65) are present in the sera of 70-80% of patients with type 1 diabetes (T1D), but antibodies to the structurally similar 67 kDa isoform GAD67 are rare. Antibodies to GAD67 may represent a cross-reactive population of anti-GAD65, but this has not been formally tested. METHODOLOGY/PRINCIPAL FINDINGS In this study we examined the frequency, levels and ...

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