objective(s) it is well known that prenatal stresses (ps) induce a variety of neurobiological and behavioral alterations, some of them involving the hippocampal formation. this study aimed to determine whether restraint stress influences the neuronal volume and number of granule cells in the hippocampus of adult rat offspring. materials and methods ten wistar pregnant rats were randomly divided...

Control over spatial distributions and patterns of individual neurons their neurites provides an essential tool for studying the meaning neuronal network patterns. Moreover, complete direction control synaptic connections between cells in each is also to investigate detailed information on relationship forward feedback signaling among cells. Here, we have developed a method topographical within...

Objective: Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of amyloid beta in the hippocampus. In recent decades, herbal medicine has been widely used to treat many neurodegenerative disorders,as in comparison to conventional drugs, herbal remedies exert minimal side effects. Here, the effects of thymoquinone, as the main active component of Nigella sativa, on ...

Background: Hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. We previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) modulates epileptogenesis in rats. There is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. Gap junction channels are formed ...

Monoclonal antibodies were generated using 5 d neonatal rat dentate gyrus as immunogen. One antibody of this panel, G6E3, recognized a cell-surface protein with an Mr = 43,000 that was found only in the nervous system. The antigen was expressed as early as embryonic day 13 in the rat in both the brain and spinal cord. In the adult rat the antigen was demonstrated immunohistochemically to be res...

Introduction: Antibiotic supplements are regularly used in neuronal culture media to control contamination however, they can interfere with the neuronal excitability and affect electrophysiological properties. Therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined. Methods: Electr...

Background: Gap junctions composed of connexins (Cx) are functional in cell defense by propagation of toxic/death molecules to neighboring cells. Hippocampus, one of the brain regions with particular vulnerability to damage, has a wide network of gap junctions. Functional response of astrocytic Cx30 and neuronal Cx32 to hippocampal damage is unknown. Methods: We infused lipopolysaccharide (LPS)...

Background and Aim: The purpose of the present study is to provide a basis for use Curcuma longa extract as therapeutic agent status epilepticus. Methods: effect on epilepticus in rat model was investigated. rat’s SE induced by pilocarpine evaluated through measurement seizure duration, brain oedema hippocampal oxidative stress this model. Results: In pre-treated with (400mg/kg) water content l...

The adult rat hippocampus was investigated by light microscopic immunocytochemistry for (Na+ + K+)-ATPase. In the CA1, CA2 and CA3 hippocampal regions, dense immunostaining for (Na+ + K+)-ATPase, exhibiting a punctate appearance, was demonstrated along the soma plasmalemma of hippocampal pyramidal cells in the stratum pyramidale, thus outlining these cells distinctly, and along dendrites extend...