Whereas the greatest relative increase in body mass occurs during the third trimester of fetal life, the source of the cholesterol that supports this growth is uncertain. These studies used [3H]water and 125I-cellobiose-labeled low density lipoproteins to quantitate absolute rates of cholesterol acquisition in vivo by the fetus of the rat. Preliminary studies demonstrated that [3H]water adminis...

Severe uteroplacental insufficiency causes cerebral apoptosis in the fetus. Moderate uteroplacental insufficiency causes intrauterine growth retardation (IUGR) and increases the risk of postnatal neurological morbidity. In the rat, uteroplacental insufficiency and IUGR affect cerebral gene expression of Bcl-2 and predispose the newborn IUGR rat toward cerebral apoptosis when challenged with per...

In the present study, the division modalities and regularity of rat cardiomyocytes from different developing stages were investigated with immunohistochemistry, transmission electron microscopy and cell culture in vitro. The results showed that the cells with mitotic figure and binuclear cells exist in the normal cardiomyocytes in prenatal and postnatal life. There are two types of binuclear ca...

We showed previously that orally administered bisphenol A (BPA) easily crosses the placental barrier and enters the fetus. However, BPA glucuronide transport and metabolism in the fetus was not studied. We examined the transport of orally administered BPA and BPA glucuronide into mature rat testis and fetus of pregnant rats. After administration of an oral dose of 10 mg BPA per kg body weight t...

701 T HE CHICK EMBRYO 15 used widely in studying drugs for teratogenic activity. Chemicals, which have been injected at the same period of incubation of the chick eml)ryo, may produce separate and characteristic patterns of developmental abnormalities. The effects of many drugs, such as insulin, azasenine, sulfanilamide, 4-aminopteroyl glutamic acid, 8-azaguanine, physostigmine, thallium, lead,...

A fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each (referred to as PL-A, PL-B, and PL-C) of this attached one fetus each, but their fetal weights were lower than that the only normal PL-N) dam. Histopathologically, thinning trophoblastic septa dilatation maternal sinusoid labyrinth zone PL-B PL-C, not PL-A or PL-N. The points placental fusion at junctional ...