Karkanis, Tom, Ling DeYoung, Gerald B. Brock, and Stephen M. Sims. Ca2 -activated Cl channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection. J Appl Physiol 94: 301–313, 2003. First published September 27, 2002; 10.1152/japplphysiol.00660. 2002.—Little is known of the excitatory mechanisms that contribute to the tonic contraction of the corpus cavernosum sm...

Erectile dysfunction is caused by a variety of pathogenic factors, particularly impaired formation and action of nitric oxide (NO). NO released from nerve endings and corpus cavernosum endothelial cells plays a crucial role in initiating and maintaining increased intracavernous pressure, penile vasodilatation, and penile erection. Classically, these effects are dependent on cGMP synthesized dur...

INTRODUCTION Neurogenic erectile dysfunction resulting from cavernous nerve (CN) injury is a major complication caused by radical prostatectomy. The use of platelet-rich plasma (PRP) on the nerve-injured site has shown promising results for the nerve regeneration. However, the effects of PRP injection in corpus cavernosum after bilateral CN injury have never been investigated. AIM To assess t...

Williams, Beatrice A., Caiqiong Liu, Ling DeYoung, Gerald B. Brock, and Stephen M. Sims. Regulation of intracellular Ca release in corpus cavernosum smooth muscle: synergism between nitric oxide and cGMP. Am J Physiol Cell Physiol 288: C650–C658, 2005. First published November 10, 2004; doi:10.1152/ajpcell.00475. 2004.—Tonic contraction of corpus cavernosum smooth muscle cells (SMCs) maintains ...

AIM To explore the mechanism of chronic renal failure (CRF)-related erectile dysfunction (ED). METHODS CRF experimental models were established by 5/6 nephrectomy from male Sprague-Dawley rats. Both the rats from the control group (NCRF group, n=6) and the experimental group (CRF group, n=30) were injected with a low dose (80 microg/kg) of apomorphine in the 12th week after resection surgery ...

PURPOSE We determined the role of purine and pyrimidine nucleotides in erectile function in diabetic rats. MATERIALS AND METHODS A total of 60 adult male rats were divided into 2 groups, including 30 controls and 30 treated with streptozotocin (60 mg/kg) for 8 weeks to induce hyperglycemia. Changes in intracavernous pressure after intracrural injections of adenosine 5'triphosphate and adenosi...

Tonic contraction of corpus cavernosum smooth muscle cells (SMCs) maintains the flaccid state of the penis, and relaxation is initiated by nitric oxide (NO), leading to erection. Our aim was to investigate the effect of NO on the smooth muscle cellular response to adrenergic stimulation in corpus cavernosum. Fura-2 fluorescence was used to record intracellular Ca(2+) concentration ([Ca(2+)](i))...

Abstract Introduction Structural alterations of penis including cavernosal apoptosis and fibrosis induce venous leakage in the corpus cavernosum or veno-occlusive dysfunction, a key pathophysiology erectile dysfunction (ED) after radical prostatectomy. Objective We aimed to determine if JNK inhibition combination with intracavernosal administration hepatocyte growth factor (HGF) would completel...