OBJECTIVE To explore the role of RAS/PI3K pathway in the impairment of long-term potentiation (LTP) induced by acute aluminum (Al) treatment in rats in vivo. METHODS First, different dosages of aluminum-maltolate complex [Al(mal)3] were given to rats via acute intracerebroventricular (i.c.v.) injection. Following Al exposure, the RAS activity of rat hippocampus were detected by ELISA assay af...

Structure of RAS-GTP: image accompanying the review article on 'RAS diseases in children' in this issue. 1650 Somatic mutations of calreticulin in myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms Luca Malcovati, et al.

The mouse Y1 adrenocortical tumor cell line is highly responsive to FGF2-(Fibroblast Growth Factor 2) and possesses amplified and over-expressed c-Ki-ras proto-oncogene. We previously reported that this genetic lesion leads to high constitutive levels of activation of the c-Ki-Ras-GTP-->PI3K-->Akt signaling pathway (Forti et al. 2002). On the other hand, activation levels of another important p...

The renin angiotensin system (RAS) recently celebrated its 100th anniversary. In 1898, renin was discovered by Tigerstedt and Bergman in rabbit kidney (Tigerstedt and Bergman, 1898). Renin turned out to be the rate limiting enzyme of a proteolytic cascade leading to the formation of angiotensin (Ang) I and Ang II. In this cascade renin splits the liverderived renin substrate, angiotensinogen (A...

He···Li2: A Theoretical Study 2 Samah Saidi,†,‡ Hamid Berriche,‡,¶ and Nadine Halberstadt*,† 3 †LCAR-IRSAMC, Universite ́ Toulouse 3 Paul Sabatier and CNRS, 31062 Toulouse, France 4 ‡Laboratoire des Interfaces et Mateŕiaux Avanceś, Deṕartement de Physique, Faculte ́ des Sciences, Universite ́ de Monastir, Avenue de 5 l’Environnement, 5019 Monastir, Tunisia 6 Department of Mathematics and Natural S...

Understanding the etiology of cognitive deficits in genetic disorders holds great promise for advancing disease-specific treatments. The availability of animal models has allowed detailed examination of molecular pathways underlying the cognitive phenotype in numerous Mendelian disorders, increasing optimism for mechanism-based treatments. One such disorder is neurofibromatosis type 1 (NF1), an...

Human tumor cells containing ras oncogenes display enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine (Ara-C) and other deoxycytidine analogues (H-M. Koo, et al., Cancer Res., 56: 5211-5216, 1996). Human tumor cell lines with or without a ras oncogene as well as a pair of isogenic cell lines with one containing an activated ras oncogene were used to study the basis for differential sensi...

Cervical cancer is one of the most severe malignant tumors since it is the second largest mortality rate that affect women’s life worldwide (Parkin et al., 2005). There are multiple pathogenesis for cervical cancer, although the primary factor in cervical cancer is infection with human papillomavirus (HPV) (Walboomers et al., 1999). Previously, treatment for cervical cancer mainly focused on ra...

Several recent papers have added new proteins that conspire with RAS, RAF, and receptors to transduce signals. These new findings raise many more questions than they answer and suggest that we need to reevaluate RAS and RAF signaling and its regulation. Pasadena, California 91125 SUR-8/SOC-2 Helps RAS EGF receptor signaling in C. elegans has been most extensively analyzed in the context of vulv...