Massive data centers housing thousands of computing nodes have become commonplace in enterprise computing, and the power consumption of such data centers is growing at an unprecedented rate. Adding to the problem is the inability of the servers to exhibit energy proportionality, i.e., provide energy-efficient execution under all levels of utilization, which diminishes the overall energy efficie...

The β2-integrin lymphocyte function-associated antigen-1 (LFA-1) plays a crucial role within the immune system. It regulates the interaction between T cells and antigen-presenting cells and facilitates T-cell adhesion to the endothelium, a process that is important for lymphocyte extravasation and homing. Signals mediated via the T-cell receptor and the chemokine receptor CCR7 activate LFA-1 th...

Ras-associated protein 1 (Rap1), a small GTPase, attracted attention because of its involvement in several aspects of cell adhesion, including integrin- and cadherin-mediated adhesion. Yet, the role of Rap1 genes and of Rap1 effectors for angiogenesis has not been investigated. Human umbilical vein endothelial cells (HUVECs) express Rap1a and Rap1b mRNA. To determine the contribution of Rap1 ac...

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that induces various types of immunotoxicity. One effect of exposure to this contaminant is alteration in cell adhesiveness. Leukocyte function-associated antigen-1 (LFA-1) plays an important role not only in T-cell recruitment into sites of inflammation and lymphoid tissues, but also in T-cell activation and i...

As the energy consumption has been surging in an unsustainable way, it is important to understand the impact of existing architecture designs from energy efficiency perspective, which is especially valuable for High Performance Computing (HPC) and datacenter environment hosting tens of thousands of servers. One obstacle hindering the advance of comprehensive evaluation on energy efficiency is t...

This paper studies a multiobjective evolutionary game theoretic framework for application placement in clouds that support a power capping mechanism (e.g., Intel’s Runtime Average Power Limit–RAPL) for CPUs. Given the notion of power capping, power can be treated as a schedulable resource in addition to traditional resources such as CPU time share and bandwidth share. The proposed framework, ca...

While the cytoskeletal protein talin binds to the β-chain of LFA-1, the immune cell adaptor SKAP1 (SKAP-55) binds to the α-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is important for LFA-1 activation, it has been unclear whether SKAP1 can alter the function of talin or its associated adaptor RIAM in T-cells. In this paper, we report that Skap1-/- T-cells sho...

Color aprial plioto~rapl~s I~ave beer1 witlely used Tor grwping most ~bptlatcrE land uses. As IIle firs: step towards t , l ~ r ! aul.omat,ic exlraction of sucl~ Features FIB roatls, Iiot~scs, etc. from color aerial photograplis, we report on tlre cvaluat.ion of several color nlorlels used ror region segmentmalion. We first transrormed the RGB color imagm into an IlSV space ljy wing one of seve...