introduction: previous studies have been shown that low frequency stimulation (lfs) has an inhibitory effect on kindling acquisition. however, the mechanism of this effect has not been completely determined. in the present study, the effect of lfs of the perforant path on seizures induced by rapid perforant path kindling was investigated. methods: animals were kindled by electrical stimulation ...

Introduction: Previous studies have shown that low frequency stimulation (LFS) has an inhibitory effect on kindling acquisition. However, the mechanism of this effect has not been completely determined. In the present study, the effect of LFS of the perforant path on seizures induced by rapid perforant path kindling was investigated. Methods: Animals were kindled by electrical stimulation of pe...

BACKGROUND Exposure to early postnatal stress is known to hasten the progression of kindling epileptogenesis in adult rats. Despite the significance of this for understanding mesial temporal lobe epilepsy (MTLE) and its associated psychopathology, research findings regarding underlying mechanisms are sparse. Of several possibilities, one important candidate mechanism is early life 'programming'...

Introduction: Application of low-frequency stimulation (LFS) is a new method for treatment of drug resistant epileptic patients. Previous studies demonstrated that activation of receptors coupled to Gi proteins is one of the mechanisms of the anticonvulsant effect of LFS. Thus, in this study, alterations in the expression of RGS4 and RGS10 proteins, as negative regulators of Gi proteins, wer...

introduction: application of low-frequency stimulation (lfs) is a new method for treatment of drug resistant epileptic patients. previous studies demonstrated that activation of receptors coupled to gi proteins is one of the mechanisms of the anticonvulsant effect of lfs. thus, in this study, alterations in the expression of rgs4 and rgs10 proteins, as negative regulators of gi proteins, were i...

Objective. Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations. Method. This experimental animal study was conducted on adult Wistar rats (200 ± 20 g) randomly divided into...

PURPOSE Neuronal migration disorders (NMD) are often found in patients with epilepsy. However, the mechanisms linking these two pathologies are not yet fully understood. In this study, we evaluated whether NMD increased kindling seizure susceptibility and seizure-induced acute neuronal damage in the immature brain. METHODS Experimental NMD were produced by exposing pregnant rats (gestation da...

Inhibition of glycolytic metabolism may provide a new therapy for refractory epilepsy. Fructose-1,6-diphosphate (FDP), which inhibits glycolysis and diverts glucose into the pentose phosphate pathway, has strong inhibitory action on seizures induced by chemical convulsants. Here, we investigated the effect of FDP on a rat model of rapid hippocampal kindling. After determining the after-discharg...

Introduction: Previous studies have been shown that low frequency stimulation (LFS) has an inhibitory effect on kindling acquisition. However, the mechanism of this effect has not been completely determined. In the present study, the effect of LFS of the perforant path on seizures induced by rapid perforant path kindling was investigated. Methods: Animals were kindled by electrical stimulatio...