We describe a patient with postsurgical anaerobic meningitis due to Peptostreptococcus magnus. In cases of meningitis associated with Peptostreptococcus species reported in the literature, the most common predisposing factors are meningorectal fistulae and head-and-neck surgery. Most patients respond well to appropriate antimicrobial therapy. Surgical intervention may be required in some instan...

The expression of the proto-oncogene c-fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased immunoreactivity bilaterally in laminae I-VI of the dorsal horn. The strongest c-FOS expression was ...

OBJECTIVES Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. MATERIALS AND METHODS To this end, tail blood flow of male Wistar rats was measured by laser doppler following the induction of hy...

Models of brain function predict that the recurrence of a process or state will be reflected in repeated patterns of correlated activity. Previous work on medullary raphe assembly dynamics revealed transient changes in impulse synchrony. This study tested the hypothesis that these variations in synchrony include distributed nonrandom patterns of association. Spike trains were recorded simultane...

Carlos F. Sanz-Navarro,† Per-Olof Åstrand,† De Chen,‡ Magnus Rønning,‡ Adri C. T. van Duin,§ Jonathan E. Mueller,§ and William A. Goddard III§ Department of Chemistry, Norwegian UniVersity of Science and Technology (NTNU), 7491 Trondheim, Norway, Department of Chemical Engineering, Norwegian UniVersity of Science and Technology (NTNU), 7491 Trondheim, Norway, and Materials and Process Simulatio...

The raphe magnus is part of an interrelated region of medullary raphe and ventromedial reticular nuclei that project to all areas of the spinal gray. Activation of raphe and reticular neurons evokes modulatory effects in sensory, autonomic, and motor spinal processes. Two physiological types of nonserotonergic cells are observed in the medullary raphe and are thought to modulate spinal pain pro...

Idem., St. Bart's Hosp. med. Rep., 1912, 43, 73. Idem., Brit. med. J., 1912, ii, 1367. Idem., Brit. J. Surg., 1914, 2, 17. Idem., The Robert Jones Birthday Volume, Oxford University Press, 1928, p. 127. Idem., J. Bone Jt Surg., 1931, 13, 423. ELMSLE, R. C., FRASER, F. R., DUNHLL, T. P., VICK, R. M., HARRIS, C. F., and DAUPHINEE, J. A., Brit. J. Surg., 1933, 20, 479. ELMsLE, R. C., Lpool med.-ch...

Physiological studies of neurons in raphe magnus (RM) and the adjacent nucleus reticularis magnocellularis (NRMC) have demonstrated that the response to noxious cutaneous stimulation predicts the response to opioid administration and therefore a cell's functional role in nociceptive modulation. Although visceral stimulation, like opioids, elicits antinociception, little is known about how RM an...

Pharmacological studies have suggested that serotonergic cells in RM contribute to both the inhibition and facilitation of spinal nociceptive transmission. Physiological studies in the medullary nucleus raphe magnus (RM) and adjacent nucleus reticularis magnocellularis have identified putative nociceptive-inhibitory OFF cells and nociceptive-facilitatory neurons ON cells by their responses to n...

In this paper entrepreneurs are defined as agents who bring about economic change by combining their own effort with other factors of production in search of economic rents. The institutional setup is argued to determine both the supply and direction of entrepreneurial activity. Four key institutions are explored more closely: property rights protection, savings policies, taxation and the regul...