conclusions barberry supplementation reduces oxidative burden in patients with metabolic syndrome. results there was no significant difference between the groups regarding their baseline pab values (p = 0.32). a significant decrease in pab was observed in the barberry group (p = 0.022), whilst there was no significant change in the control group (p = 0.18). the magnitude of change in pab during...

The randomized controlled trial (RCT) is regarded as one of the most valued research methodologies for examining the efficacy or effectiveness of interventions.1 Randomized trials are most often associated with studies of drug effectiveness; however, they have also been successfully applied to research questions related to provision of care by pharmacists.2-5 This article is not intended to be ...

conclusions the evidence that btx-a decreases ntg-induced cgrp-li and sp-li levels in trigeminovascular system suggests that btx-a attenuates migraine by suppression of neuropeptide release. btx-a injections for migraine at acupoint-sites and fixed-sites are effective. acupoint-sites btx-a administration shows more efficacy for migraine than fixed-sites application. results local btx-a injectio...

BACKGROUND Randomized placebo-controlled trials represent the gold standard in evaluating healthcare interventions but are rarely performed within orthopedics. Ethical concerns or well-known challenges in recruiting patients for surgical trials in general have been expressed and adding a placebo component only adds to this complexity. The purpose of this study was to report the challenges of re...

Objective: This chapter serves as a narrative review of the randomized controlled trial (RCT) evidence demonstrating reduction in lung cancer mortality with low-dose computed tomography (LDCT) and interaction aspects that contribute to an effective screening program.

BACKGROUND Attention-deficit/hyperactivity disorder (ADHD) is a common neurological disorder affecting 5 % of children worldwide. A prevalent problem for children with ADHD is initial insomnia. The gold standard treatment to manage ADHD symptoms is stimulant medications, which may exacerbate the severity of existing initial insomnia. Currently, no gold standard treatment option exists for initi...

background: tocotrienols have been shown to improve glycemic control and redox balance in an animal study, but their effects on patients with diabetes are unknown. the study aimed to investigate whether tocotrienols improves glycemic control, insulin sensitivity,and oxidative stress in individuals with type 2 diabetes mellitus (t2dm). materials and methods: this study was a double-blinded,place...