background: the aim of this work was to study the feasibility of constructing a fast thorax model suitable for simulating lung motion due to respiration using only one ct dataset. materials and methods: for each of six patients with different thorax sizes, two sets of ct images were obtained in single-breath-hold inhale and exhale stages in the supine position. the ct images were then analyzed ...

background: pulmonary complications of radiation to breast are inevitable, while its incidence and severity are not clear. one of the methods to assess pulmonary complications is spirometry. the influence of radiotherapy on pulmonary function test and the factors affecting it have been assessed in this study. methods: breast cancer patients with stage ii and iii (based on tnm staging), underwen...

background: radiation-induced lung toxicity is an important dose-limiting toxicity in lung cancer radiotherapy, for which there are no generally accepted predictive factors. this study seeks to identify risk factors associated with the development of severe radiation-induced lung toxicity using clinical and dosimetric parameters. methods: we reviewed the medical records of 54 patients with hist...

Background: Prediction of the absorbed dose in irradiated volume plays an important role in the outcome of radiotherapy. Application of small fields for radiotherapy of thorax makes the dose calculation process inaccurate due to the existence of electronic disequilibrium and intrinsic deficiencies in dose calculation algorithms. To study the lung absorbed dose in radiotherapy with smal...

the liver is an organ at risk (oar) in radiotherapy of thoracic and abdominal tumors such as gastric, distal esophagus, lower lung and breast, bile duct, pancreas and whole abdomen. in this study the alteration in liver functional tests (lft) of these patients during radiotherapy was investigated. to that end, the level of serum aspartate aminotransferase (ast), alanine aminotransferase (alt), ...

background: the dosimetric parameters required in lung cancer radiation therapy are taken from a homogeneous water phantom; however, during treatment, the expected results are being affected because of its inhomogeneity. therefore, it becomes necessary to quantify these deviations. objective: the present study has been undertaken to find out inter- and intra- lung density variations and its dos...

objective: free radicals generated by ionizing radiation attack various cellular components such as lipids. the lung is a very radiosensitive organ and its damage is a doselimiting factor in radiotherapy treatments. melatonin (mlt), the major product of the pineal gland acts as a radioprotective agent. this study aims to investigate the radioprotective effects of mlt on malondialdehyde (mda) le...

Introduction: Whole breast radiotherapy after breast-conserving surgery decrease the risk of local recurrence. this study investigates the dosimetric aspects of intensity modulated radiotherapy (IMRT) compared to conventional tangential wedge-based beams techniques (CTT) of the whole breast in early stages breast cancer patients.   Materials and Methods: Co...

Background: Inclusion of inhomogeneity corrections in intensity modulated small fields always makes conformal irradiation of lung tumor very complicated in accurate dose delivery.Objective: In the present study, the performance of five algorithms via Monte Carlo, Pencil Beam, Convolution, Fast Superposition and Superposition were evaluated in lung cancer Intensity Modulated Radiotherapy plannin...

background: radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. materials and methods: 50 female wistar rats were randomly divided into 5 groups, average 10 rats/cage: a. control group b. 3gy×10f c. 6gy×5f d. 12.5gy×1f e.15.3gy×1f. by different doses of r...