Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

BACKGROUND Hypothyroidism is a known consequence of external beam radiotherapy to the neck encompassing part or whole of the thyroid gland for over 40 years. Still thyroid function tests are not a part of routine follow up of head - neck cancer patients treated with radiotherapy with or without surgery and / or chemotherapy. AIM Aim of this study was to find out the incidence of hypothyroidis...

The objective of this study was to find out the radiation dose relationship with subclinical hypothyroidism in postoperative head and neck squamous cell carcinoma patients, who underwent adjuvant external beam radiotherapy. It a prospective cohort done between June 2018 January 2020. One hundred were fulfilling criteria histological proven (SCC) AJCC stage I III, enrolled. Patients irradiated f...

Results Thirty-four patients were included in the study. The median age at diagnosis was 7.5 years (range = 0.8 17.2 years) and the median follow-up time was 10.45 years (range = 2 – 18.3 years). Hypothyroidism was diagnosed in 16 patients (Primary hypothyroidism = 5 patients; compensated hypothyroidism = 10 patients; central hypothyroidism = 1 patients) and it was the commonest endocrine compl...

Introduction: During treatment of breast cancer, Radiotherapy to the Supraclavicular fossa region results in absorption of radiation by the thyroid gland and consequently leads to hypothyroidism in 40% of patients. The aim of this study was to compare thyroid gland radiation absorption during radiotherapy with different anterior-posterior beam radiation of 6-15 and 15-15 MV pho...

Radiotherapy and hypothyroidism are unusual causes of acquired atrioventricular block (AVB). Thoracic radiotherapy used for the treatment of different neoplasms may cause adverse cardiac1,2 and endocrinologic3 events, attributed to fibrosis of the conduction tissue and the thyroid gland, respectively. The infra-Hisian localization of an AVB is uncommon in young patients, but nevertheless of gre...