The radiobiological effects of highly-charged-ion beams are of interest for tumortherapy and for radioprotection in space. In tumor therapy, high-energy protons and carbon ions exhibit an inverse dose profile, i.e. an increase of energy deposition with penetration depth. This allows a greater tumor dose for protons and carbon ions than for photons. In addition, for the heavier carbon ions, this...

1 IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U896, Montpellier, F-34298, France; Université Montpellier1, Montpellier, F34298, France; CRLC Val d’Aurelle Paul Lamarque, Montpellier, F-34298, France; 2 CRLC Val d’Aurelle-Paul Lamarque, F-34298 Montpellier, France; 3 Service de Médecine Nucléaire, CHU de Nîmes, Nîmes F-30029, France; 4 Direct...

The dose limiting toxicities of Ionizing Radiation (IR) in radiosensitive normal tissues, such as bone marrow, intestine, and skin, precludes the delivery of curative or effective palliative doses of radiation in many cases. Despite of the intense research effort in the past to find new effective and well-tolerated radioprotectors, only one drug has been approved by FDA for this indication. One...

Studies of radioresistance and radioprotection provide an excellent in vivo model for dissection of the pathophysiological role of cytokines. The availability of neutralizing antibodies to cytokines has made it possible to assess the contribution of cytokines to host defense and repair processes involved in radioresistance and radioprotection. Administration of anti-interleukin 1 receptor (IL-1...

The development of a system capable of ensuring adequate protection of the environment from the harmful effects of ionising radiation is at present particularly debated. This need comes both from a restrictive consideration of the environment in the so far existing system for human radioprotection, and the planetary-wide growing concerns about man's technogenic influence on his environment whic...

Hematopoietic stem cells (HSCs) are defined in mice by three activities: they must rescue lethally irradiated mice (radioprotection), they must self-renew, and they must restore all blood cell lineages permanently. We initially demonstrated that HSCs were contained in a rare ('~0.05%) subset of bone marrow cells with the following surface marker profile: Thy-l.1 l~ LinSca-l+. These cells were c...