Mathematical models of chronic myeloid leukemia (CML) cell population dynamics are being developed to improve CML understanding and treatment. We review such models in light of relevant findings from radiobiology, emphasizing 3 points. First, the CML models almost all assert that the latency time, from CML initiation to diagnosis, is at most ∼10 years. Meanwhile, current radiobiologic estimates...

Treatment of prostate cancer with SBRT is an area of significant controversy for many in the radiation oncology community despite radiobiologic data that strongly suggest the prostate would be an excellent SBRT target. Recently, new data have emerged that show promising outcomes with minimal toxicity for CyberKnife SBRT of prostate cancer. In the following we present the motivating factors for ...

BACKGROUND Purpose of this study is to explore the trade-offs between radio-induced toxicities and second malignant neoplasm (SMN) induction risk of different emerging radiotherapy techniques for Hodgkin's lymphoma (HL) through a comprehensive dosimetric analysis on a representative clinical model. METHODS Three different planning target volume (PTVi) scenarios of a female patient with suprad...

The development of radionuclide therapies during the past few decades provides a growing body of data on radiobiologic effects, including normal tissue toxicities and antitumor efficacy. Information on normal tissue toxicity from radionuclides is more limited than that from external beam radiation and appears to be more variable. Much of the increased variability is attributed to heterogeneous ...

UNLABELLED Abstract Objective: To assess the impact of nonuniform dose distribution within lesions and tumor-involved organs of patients receiving Zevalin(®), and to discuss possible implications of equivalent uniform biological effective doses (EU-BED) on treatment efficacy and toxicity. MATLAB™ -based software for voxel-based dosimetry was adopted for this purpose. METHODS Eleven lesions fr...

A section of this issue of TCRT focuses on four articles dealing with technological advances in brain and spine radiosurgery. With the evolution of radiation technology to allow for high precision image-guided radiotherapy as an integrated part of mainstream linear accelerators, the practice of stereotactic radiosurgery (SRS) is commonly applied to the brain and is rapidly developing as an attr...

PURPOSE Using current radiobiologic models and biologic parameters, we performed an exploratory study of the clinical consequences of hypofractionation in prostate cancer radiotherapy. METHODS AND MATERIALS Four hypofractionated treatment regimens were compared with standard fractionation of 2 Gy x 39 for prostate carcinoma using a representative set of anatomical structures. The linear-quadr...