Radiation-induced lung injury is a serious complication following thoracic irradiation for the treatment of lung, breast, or hematologic malignancies. Two distinct lung injury patterns have been described: early radiation pneumonitis and late radiation fibrosis. Both syndromes commonly include dyspnea and cough. The chest radiograph invariably shows pulmonary infiltrates. The following case des...

To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of radiation pneumonitis and to determine whether the measurement of soluble ICAM-1 (sICAM-1) levels is useful for predicting the onset of pneumonitis, the levels of sICAM-1 were measured in serum and bronchoalveolar lavage (BAL) fluids from patients with lung malignancy who received radiotherapy. A total ...

normal 0 false false false en-us x-none ar-sa background: breast cancer is the most common type of cancer among women, and the second cause of cancer mortality after pulmonary cancer in this gender. radiotherapy is one of the major treatments, which locally controls the disease and prohibits in recurrency. radiation pneumonitis is one of the radiotherapy complications, which usually occurs with...

BACKGROUND Taxane-based chemotherapy has been associated with an increased risk of radiation pneumonitis in patients with breast cancer. To obtain additional information about this association, we investigated the association between paclitaxel chemotherapy and radiation pneumonitis in patients participating in a phase III randomized study. METHODS Five hundred and twenty-four breast cancer p...

BACKGROUND AND OBJECTIVE Research has confirmed that transforming growth factor-beta1 (TGF-beta1) is one of the cytokines related to radiation pneumonitis. But the level of TGF-beta1 in serum needed to predict radiation pneumonitis is still not clear. This study assessed the value of TGF-beta1 in both serum and induced sputum in predicting radiation pneumonitis, providing a reference for the ra...

OBJECTIVE To examine the effects of dose-volume factors on the development of radiation pneumonitis in patients with non-small-cell lung cancer who received twice-daily radiotherapy concurrently with carboplatin and paclitaxel chemotherapy. METHODS Radiotherapy consisted of twice-daily fractionation of 1.2 Gy, to a total dose of 60 Gy. Weekly carboplatin and paclitaxel were used as a concurre...

BACKGROUND Some chemotherapy (CT) drugs, including taxanes, may enhance the effectiveness of radiation therapy (RT). However, combining these therapies may increase the incidence of radiation pneumonitis, a lung inflammation. In a retrospective cohort study, we evaluated the incidence of radiation pneumonitis in breast cancer patients treated with RT and standard adjuvant CT by use of doxorubic...

TOPIC: Imaging TYPE: Fellow Case Reports INTRODUCTION: Radiation pneumonitis (RP) usually occurs 3-6 months after radiation and fibrosis within 6-12 months. We report a patient who developed the classic imaging features of RP 2 years 6 initiation chemotherapeutic agent – Paclitaxel, consistent with phenomenon recall (RRP). RRP can occur when agents such as doxorubicin, erlotinib, etoposide, gem...

Radiation pneumonitis is a clinical problem with a high incidence. Once the onset of radiation pneumonitis has occurred, the administration of antioxidants and anti-inflammatory agents is the most commonly used method of clinical treatment. Quercetin (Que) is a common flavonoid, with potent anti-inflammatory and anti-oxidant activities. In the present study, the therapeutic effect of inhaled Qu...

OBJECTIVE To evaluate acute morbidity, radiation dermatitis and pneumonitis, of Japanese patients treated with whole breast hypofractionated radiotherapy (RT) after breast-conserving surgery (BCS), compared to conventional RT. METHODS Japanese patients who received whole breast RT after BCS between October 2003 and September 2006 were retrospectively reviewed. Patients who had selected the co...