Human cytoplasmic alpha-fetoprotein (AFP) has been classified as a member of the albuminoid gene family. The protein sequence of AFP has significant homology to that of human serum albumin (HSA), but its biological characteristics are vastly different from HSA. The AFP functions as a regulator in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway, but HSA plays a key role a...

PURPOSE We examined the influence of body mass index (BMI) and body fat distribution on rectal dose in patients treated with permanent seed brachytherapy for localized prostate cancer. METHODS AND MATERIALS We analyzed 213 patients treated with I125 seed brachytherapy for localized prostate cancer. BMI and rectal dosimetry data for all patients were available. Data on visceral and subcutaneou...

BACKGROUND South Africa is providing antiretroviral (ARV) drugs for HIV/AIDS free of charge in order to increase access for poorer patients and promote adherence. However, non-drug costs of obtaining treatment may limit access. We estimated the costs that South African patients incur in obtaining antiretroviral therapy (ART). METHODS A random sample of adult pre-ART and ART patients attending...

Protistan community structure was examined from 6 depths (1.5, 20, 42, 150, 500, 880 m) at a coastal ocean site in the San Pedro Channel, California. A total of 856 partial length 18S rDNA protistan sequences from the six clone libraries were analyzed to characterize diversity present at each depth. The sequences were grouped into a total of 259 Operational Taxonomic Units (OTUs) that were infe...

Bremer K, Monk CT, Gurd BJ, Moyes CD. Transcriptional regulation of temperature-induced remodeling of muscle bioenergetics in goldfish. Am J Physiol Regul Integr Comp Physiol 303: R150 –R158, 2012. First published May 23, 2012; doi:10.1152/ajpregu.00603.2011.—Central to mammalian mitochondrial biogenesis is the transcriptional master regulator peroxisome proliferator-activated receptor (PPAR)co...

INTRODUCTION Substantial evidence describes the protective effects of marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFA) on cardiovascular diseases as well as many other conditions. Numerous fatty acid preparations are marketed for supplementing the Western diet, which is low in n-3 fats. Since these preparations may vary in their n-3 PUFA content, we tested 45 commercially availab...

The paper developed a computer model of the thermal and stress-strain state three-story car parking building, which consists fire-resistant structures, taking into account: thermophysical characteristics coatings, mechanical properties materials that make up structure, nonlinear laws deformation materials, at high temperature force. Modeling non-stationary heating reinforced concrete column wit...

Anaerobic digestion (AD) is used to produce biogas and can offer a solution in waste management. Digestate, the AD by-product, be applied soil improve fertility. However, response of biological communities not fully understood. There are mixed reports on its impact earthworm survival. This study aimed investigate digestate effects mortality, elucidate potential mechanisms underlying it, if obse...

Background: Axial spondyloarthritis (axSpA) is a common chronic inflammatory disease, associated with extracellular matrix (ECM) remodeling of the cartilage, bone and connective tissues. The primary symptom axSpA back pain, caused by inflammation. However, there medical need to truly identify patients from other subjects buttock or low pain attributable reasons. Tissue-derived markers quantifie...

Abstract This paper proposes an approach to find an optimum structure for educational levels of human forces. To this end, a Linear Programming (LP) Model integrated with a Social Accounting Matrix (SAM) was employed. The integrated model was employed using the SAM of Golestan Province of Iran. It was demonstrated that when unemployment is the result of inconsistency between supply and demand...