Urothelial carcinoma of the bladder (UCB) is the most common malignancy of the urinary tract, nearly half of which contains a mutation in TP53 gene. Hence, therapeutic approach by restoring functional p53 protein in cancer cells will be beneficial. Recent studies have demonstrated the inhibition of cancer cell growth by p53 reactivation using a peptide derived from the p53 C-terminus (p53C). Ho...

Climate fluctuations have been linked to an increased prevalence of disease in seaweeds, including the red alga Delisea pulchra, which is susceptible to a bleaching disease caused by the bacterium Nautella italica R11 under elevated seawater temperatures. To further investigate the role of temperature in the induction of disease by N. italica R11, we assessed the effect of temperature on the ex...

Article history: Received 14 August 2007 Revised 8 July 2008 Available online 23 August 2008 JEL classification: J61 J64 E24 P23 R11 O33

PURPOSE We investigated the ability of the fusion protein granulocyte-macrophage colony-stimulating factor and carbonic anhydrase IX (GMCA-9)(1) to induce an immune response in vitro and in vivo for the development of a GMCA-9-based kidney cancer vaccine. EXPERIMENTAL DESIGN Human dendritic cells (DCs) were transduced with a recombinant adenovirus containing the GMCA-9 gene and tested for the...

Limited studies have compared BIM’s impacts on project performance via business types, working experience, and locations. A survey was conducted results found that (1) BIM helped with the early detection of design errors (R1), pre-construction RFIs (R2), number repeat customers (R12), but negatively affected other 9 indicators (R3~R11); (2) for R1/R2/R12, contractors, international projects, st...

There is increasing evidence to suggest that macroalgae (seaweeds) are susceptible to infectious disease. However, to date, little is known about the mechanisms that facilitate the colonization and virulence of microbial seaweed pathogens. One well-described example of a seaweed disease is the bleaching of the red alga Delisea pulchra, which can be caused by the bacterium Nautella italica R11, ...