There is no lack of debate in the field of mediation. Topics that tend to attract the most attention and vigorous discussion include mediator qualification and process outcome. What's lacking, according to Douglas Noll, is a practical theory that would bring together different views, and help both practitioners and clients. In the following article, Noll reviews existing literature to form a si...

Equipment qualification is the way to ensure that analytical equipment is fit for purpose. Qualification consists of four basic elements. Design qualification or DQ (Specification of what exactly the analytical scientist requires the equipment to do). Installation qualification or IQ (Does the instrument work to the manufacturer’s specification?). Operational qualification or OQ (Does the instr...

Biomarkers may be qualified using different qualification processes. A passive approach for qualification has been to accept the end of discussions in the scientific literature as an indication that a biomarker has been accepted. An active approach to qualification requires development of a comprehensive process by which a consensus may be reached about the qualification of a biomarker. Active ...

The SafeTITM Compiler Qualification Kit is a modern, model-based qualification kit that offers a high degree of flexibility during application of the kit. This paper will describe challenges posed by the safety standards and processes, as well as illustrate the benefits of model-based tool qualification. The second part of the paper focuses on the Texas Instruments C/C++ ARM® compiler specific ...

background and objectives: the microbiological monitoring of the water used for haemodialysis is important especially for legionella and non-fermentative bacteria since patients with end stage renal disease (esrd) are suffering from deteriorated function of immune system. materials and methods: a total 50 water and dialysate samples were weekly collected over a period of 10 weeks from 5 sites. ...

Inspection qualification is the term currently used to describe the process of independent assessment of a specific non-destructive test to ensure that it is capable of meeting its objectives. Such activities carried out on the Sizewell B reactor inspections were referred to as validation. In the USA, the term performance demonstration is used, though this is increasingly being reserved for the...

In this paper we consider a mathematical program with equilibrium constraints (MPEC) formulated as a mathematical program with complementarity constraints. Various stationary conditions for MPECs exist in literature due to different reformulations. We give a simple proof to the M-stationary condition and show that it is sufficient for global or local optimality under some MPEC generalized conve...

We study a general multiobjective optimization problem with variational inequality, equality, inequality and abstract constraints. Fritz John type necessary optimality conditions involving Mordukhovich coderivatives are derived. They lead to Kuhn-Tucker type necessary optimality conditions under additional constraint qualifications including the calmness condition, the error bound constraint qu...

The growing adoption of safety standards in the automotive industry results in an increasing interest in as well as an increasing uncertainty about software tool certification and qualification. With ISO 26262 on the horizon, new tool qualification requirements need to be understood and implemented by automotive software practitioners. This paper summarizes the tool qualification approach of IS...

In this paper we consider the bilevel programming problem (BLPP), which is a sequence of two optimization problems where the constraint region of the upper-level problem is determined implicitly by the solution set to the lower-level problem. We extend well-known constraint qualifications for nonlinear programming problems such as the Abadie constraint qualification, the Kuhn-Tucker constraint ...