BACKGROUND This study was performed to determine the changes in corrected QT (QTc) and QT dispersion and their relationship with end-stage liver disease score in the children undergoing orthotopic liver transplantation. METHODS This case-control study was performed in a 2-year period from February 2009 to March 2011 in Department of Organ Transplantation of Nemazee Hospital. We consecutively ...

Background: We designed a cross-sectional study to determine electrocardiographic disorders in Down syndrome patients with congenitally normal hearts in a bid to predict fatal cardiac arrhythmia in the future. Materials and Methods: We investigated 60 children with DS without congenital abnormal hearts. Sixty healthy juveniles were also included in the study as a control group. Physical examina...

BACKGROUND Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy, disarray, fibrosis, and increased risk for ventricular arrhythmias. Increased QT dispersion has been reported in patients with HCM, but the underlying mechanisms have not been completely elucidated. In this study, we examined the relationship between diffuse interstitial fibrosis, replacement fibrosis, QTc dis...

Background: Cardiovascular mortality and morbidity are high in chronic renal failure (CRF) patients. Increased dispersion of QT intervals is known to predispose to ventricular arrhythmias and sudden cardiac death. This study was conducted to assess the effect of hemodialysis (HD) on corrected QT (QTc) intervals and their dispersions (QTd) in chronic hemodialyzed patients. Methods: Fifty-eight p...

BACKGROUND HD has been reported to determine an increase in QTc interval and QTc dispersion (QT(max)-QT(min))-risk factors that predispose to severe ventricular arrhythmias and sudden death. However, most studies have included end-stage renal disease (ESRD) patients with significant heart pathology. We therefore aimed to study the impact of a single HD session in subjects without manifest cardi...

INTRODUCTION The electrocardiography (ECG) markers of corrected QT interval (QTc) and QTc dispersion are prolonged in patients on hemodialysis. This study was carried out to investigate if changes in these markers will reverse by successful kidney transplantation. MATERIALS AND METHODS Twenty-six kidney allograft recipients with functioning grafts, 26 patients on maintenance hemodialysis, and...

OBJECTIVE Glycemic variability (GV) is a new term with the episodes of hyper and hypoglycemia in diabetic patients. Both prolonged QT interval and QTd are potential risk factors for malignant ventricular arrhythmias affecting the mortality of different groups of patients including diabetes mellitus. In this study, we aimed to evaluate if the glucose variability increasing the QTc interval and Q...

BACKGROUND Patients with end-stage kidney disease (ESKD) experience elevated cardiac stress because of the repetitive and intermittent character of dialysis. Changes in ventricular electrical systole induced by necessary dialysis significantly contribute to predict sudden death due to arrhythmia in ESKD. OBJECTIVE The major objective of this study was to assess the behavior of ventricular rep...

and Hyperinsulinemia To the Editor: QTc dispersion is an important predictor of cardiac mortality. In the Rotterdam Study,1 persons in the highest tertile (.60 ms) relative to the lowest tertile (,39 ms) of QTc dispersion had a 2-fold risk of cardiac death. The Rotterdam Study also confirms that QTc dispersion is larger in diabetic than in nondiabetic persons. QTc duration and QTc dispersion ar...

BACKGROUND Altered cardiac repolarization and increased dispersion of repolarization have been identified as risk factors for sudden cardiac death (SCD). The prevalence of and the mechanisms contributing to altered cardiac repolarization are currently unknown in COPD. METHODS In 91 COPD patients, 32 controls matched for age, cardiovascular risk and medication, and 41 healthy subjects, measure...