A series of substituted triazin-pyridazine compounds were exhibited diverse types of biological activities and synthesized by different methods. These compounds were mainly tested for their anti-inflammatory, anticancer, antifungal and antibacterial activities. These substituted triazin-pyridazine compounds have mild to potent activities on compare with their appropriate reference standards.

The molecular structure of pyridazine in the first electronically excited state (S(1)) is deduced from the combined use of resonance-enhanced two-photon ionization and mass-analyzed threshold ionization spectroscopic methods. The equation-of-motion coupled-cluster single and double (EOM-CCSD) calculation gives the distorted planar geometry for the most stable structure of the S(1) pyridazine. T...

The reaction of the polymers [Au2Cu2(C6X5)4(NCMe)2]n (X = Cl (1), F (2)) with the aromatic N-donor ligand pyridazine in different molar ratios gives rise to new Au(i)/Cu(i) heterometallic complexes [AuCu(C6Cl5)2(μ2-C4H4N2)(NCMe)]2 (3), [AuCu(C6X5)2(μ2-C4H4N2)(C4H4N2)]2 (X = Cl (4), X = F (6)) and [Cu2(μ2-C4H4N2)3(NCMe)2][Au(C6F5)2]2 (5). In all cases, the close proximity of the donor atoms in t...

The reaction of symmetrical ligands based on 3,6-di(2-pyridyl)pyridazine () with carbocyclic rings fused to the pyridazine ring; 7,10-di(2-pyridyl)-8,9-diazafluoranthene (), 1,4-di(2-pyridyl)-6,7-dihydro-5H-cyclopenta[d]pyridazine (), 1,4-di(2-pyridyl)-5,6,7,8-tetrahydrophthalazine (), 1,4-di(2-pyridyl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyridazine () in reactions with zinc perchlorate gave a s...

In the crystal structure of the title compound, [Zn(3)(NCSe)(4)(OH)(CN)(C(4)H(4)N(2))(4)](n) one of the two crystallograph-ically independent zinc(II) cations is coordinated by two terminal N-bonded seleno-cyanato anions and two N atoms of two symmetry-related pyridazine ligands in a trigonal-bipyramidal geometry, while the other zinc(II) cation is coordinated by one terminal N-bonded seleno-cy...

In the title mol-ecule, C(11)H(12)N(2)O, the pyridazine ring has a skew-boat conformation. The dihedral angle between the phenyl ring [r.m.s deviation = 0.0039 (15) Å] and the best mean-plane of the pyridazine ring [r.m.s deviations = 0.2629 (15) Å] is 53.27 (10)°. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds and C-H⋯π inter-actions involving the methyl group and the phenyl rin...

In the title compound, C9H13N3O3, the morpholine ring adopts a chair conformation and its mean plane makes a dihedral angle of 68.00 (11)° with the pyridazine ring. The carbonyl O atom deviates from the plane of the pyridazine ring by 0.0482 (12) Å. An intra-molecular C-H⋯O hydrogen bond occurs. In the crystal, mol-ecules are linked by O-H⋯O and C-H⋯O hydrogen bonds, forming chains along [1-10].

Nature of a large number of pyridine N-oxide-metal complexes 1) has been investigated in detailes, and pyridazine and its derivatives are also known to afford complexes with a variety of metal ions. ‘I However, no attention has been given to complex formation between pyridazine N-oxides(I) and metal ions. 3) It is interesting to examine the structures and properties of the complexes of I becaus...

The title compound, C(18)H(16)N(2)O, is a new dihydro-pyridazin-3(2H)-one derivative synthesized in one step by condensation of α-benzyl-idene-γ-tolyl-butenolide with hydrazine. The mol-ecule is not planar; the tolyl and pyridazine rings are twisted with respect to each other making a dihedral angle of 27.35 (9)° and the benzyl ring is nearly perpendicular to the pyridazine ring with a dihedral...

Pyridazine nucleus exhibited immense pharmacological activities. Pyridazine nucleus is present in various compounds that possess remarkable pharmacological activities. Various pyridazinone compounds have antitumor activity. Some of them pyridazinone derivatives bearing different moieties were exhibited excellent anticancer activity toward human cancer cell lines. They showed remarkable activity...