The efficacy of ivermectin, fenbendazole, pyrantel pamoate and doramectin was evaluated under field conditions at 2 sites in the Free State Province of South Africa. The study involved 25 horses at each site, divided into 5 groups of equal size. Ivermectin, fenbendazole and pyrantel pamoate were administered orally at doses of 0.2, 10 and 19 mg/kg respectively. Doramectin was administered by in...

The efficacy of pyrantel embonate (1,4,5,6-tetrahydro-1-methyl-2-(trans-2-(2-thienyl)-vinyl)-pyrimidine embonic acid salt; Combantrin) was evaluated in 60 cases of hookworm infestation. They were divided into six groups of 10 cases. Pyrantel embonate was administered orally, in dosage schedules (randomized) of 100, 75, 50, 20, 15, and 10 mg/kg of body weight. The stool examination for hookworm ...

Pyrantel has been demonstrated (Bumbalo et al., 1969; Desowitz et al., 1970; Hsieh, 1971) to be effective for treatment of Ascaris, hookworm and Enterobuis. Oxantel has been shown (Zaman and Sabapaty, 1975; Garcia, 1976; Lee et al., 1976; Rim et al., 1976) to be effective against Trichuriasis. A combined Oxantel-pyrantel salts has been shown (Rim et al., 1975; Lim, 1978; Dissanaike, 1978; Cabre...

The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD50 for 5 consecutive days a...

Sport and leisure horses in Morocco are treated with several anthelmintics, organophosphates (dichlorvos), benzimidazoles (mostly thiabendazole) or tetrahydropyrimidines (mostly pyrantel pamoate) against nematodes. We studied three horse stables in Rabat, one in Meknes and one in Bouznika. Two of the Rabat and Bouznika stables had introduced a large number of horses from countries (Argentina or...

Introduction: Continued endemicity of intestinal nematodes infestation in children in our environment despite availability of potent and safe anthelmintic drugs is of public health interest. Objective: This study assessed the comparative efficacy of selected anthelmintic drugs namely Mebendazole, pyrantel pamoate and levamisole-against common intestinal nematodes namely Ascaris lumbricoides, Ho...

the effect of a combination of oxantel- pyrantel with a single dose of 10 mg/ kg body weight on trichuris trichiura, ascaris, trichostrongylus spp. and ancylostoma duodenale has been evaluated among the population of two rural areas in khuzestan, southwest iran (41 persons) and isfahan, central (30 persons). all patients were infected with trichuris trichiura and some simultaneously with one or...

Richards J. C., Rebnke J. M. & Duce I. R. 1995. In uifro studies oo tbe relative sensitivity to ivermectin of Necator americanus and AncyIostoma ceyhnicum. International Journal for Parasitology 25: 1185-1191. Experiments were carried out to compare tbe sensitivity of Ancylostoma ceyhnicum and Necator umericunus to ivermectin (IVM) and pyrantel in vitro. Loss of motility and inhibition of inges...

A study was undertaken to examine the effect of the oral administration of dimethoate and/or pyrantel on the activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and the concentration of malondialdehyde (MDA) in the liver of rats. Dimethoate was administered to the animals at a dose of 38.7 mg/kg b.w. for 5 consecutive days and pyrantel at a dose of 400 mg/kg b.w. for 3 con...

Anthelmintic products form the basis of helminth control practices on horse stud farms at present. Regular evaluation of the efficacy of these products is advisable, as it will provide information on the worm egg reappearance period and the resistance status in the worm population. The aim of this study was to evaluate the efficacy of doramectin, pyrantel pamoate, ivermectin and moxidectin on a...