conclusions high-level antibiotic resistance can occur as a result of multidrug efflux pumps combined with other mechanisms of resistance. however, the association between over-expression of these genes and highly resistant clinical isolates cannot be ignored. results our results confirmed 203 and 60 p. aeruginosa isolates from burn and non-burn specimens, respectively. the most antibiotic resi...

conclusions this study indicated that the delivery rate accuracy of elastomeric infusion pumps is preserved after repeated usage. these laboratory findings suggested that elastomeric pumps could be safely refilled in the successive days to provide postoperative analgesia. results the mean flow rate in the three series of measurements showed a gradual increase; however, the difference was not st...

  Target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in Pseudomonas aeruginosa. We performed a genotypic characterization of three major Mex multidrug efflux pumps (MexAB-OprM, MexXY-OprM and MexCD-OprJ) in ciprofloxacin resistant clinical isolates of P. aeru­ginosa, collected from Tehran, Iran this was followed by sequencin...

Abstract Liposomes are used widely as drug delivery systems in different forms including nanosuspensions, osmotic pumps, infusion pumps and IV injections. Some of these systems (e.g. infusion or osmotic pumps) might stay stagnant for a long time during or before administration, and therefore, might face phase separation. In spite of these, there is no data available about the behavior of lipos...

Abstract Liposomes are used widely as drug delivery systems in different forms including nanosuspensions, osmotic pumps, infusion pumps and IV injections. Some of these systems (e.g. infusion or osmotic pumps) might stay stagnant for a long time during or before administration, and therefore, might face phase separation. In spite of these, there is no data available about the behavior of lipos...

BACKGROUND The objective was to quantify hydrostatic effects on continuous subcutaneous insulin infusion (CSII) pumps during basal and bolus insulin delivery. METHODS We tested CSII pumps from Medtronic Diabetes (MiniMed 512 and 515), Smiths Medical (Deltec Cozmo 1700), and Insulet (OmniPod) using insulin aspart (Novolog, Novo Nordisk). Pumps were filled and primed per manufacturer's instruct...

I nsulin pump therapy—continuous subcutaneous insulin infusion (CSII)—was developed in the UK in the 1970s. Rapid technological developments changed the initial pumps from the size of a house brick, charged by mains electricity to an acceptable dimension, battery driven. We described the use of pumps in young people with type 1 diabetes (T1D) in the UK in Archives of Disease in Childhood in the...

Comparative evolutionary studies have greatly aided our understanding of how the heart develops. Two recent articles from Benoit Bruneau’s laboratory reveal the power of the so-called evo-devo approach and provide yet further details of development, both of the heart itself and of the cells that build it. Thanks to our many and varied primitive cousins, developmental biologists are gaining a go...