Sickle cell disease (SCD) is characterized by microvascular occlusion mediated by adhesive interactions of sickle erythrocytes (SSRBCs) to the endothelium. Most in vitro flow adhesion assays measure SSRBC adhesion during continuous flow, although in vivo SSRBC adhesive interactions occur during pulsatile flow. Using a well-plate microfluidic flow adhesion system, we demonstrate that isolated SS...

In this study, pulsatile and nonpulsatile assisted circulation were compared to evaluate renal circulation under complete artificial circulation. In addition, differences were also compared between animals supported by high (assist rate 80%)- and low (assist rate 60%)-level artificial circulation. Using 20 pigs, ventricular fibrillation was induced after cardiogenic shock, assist by mechanical ...

To investigate the effects of pulsatile and continuous pediatric ventricular assist (PVAD) flow and pediatric blood viscoelasticity on hemodynamics in a pediatric aortic graft model. Hemodynamic parameters of pulsatility, along with velocity and wall shear stress (WSS), are analyzed and compared between Newtonian and viscoelastic blood models at a range of physiological pediatric hematocrits us...

PURPOSE Cardiopulmonary bypass is still a major cause of lung injury and delay in pulmonary recovery after cardiac surgery. Although it has been shown that pulsatile flow induced by intra-aortic balloon pumping is beneficial for preserving lung function, it is not clear if the same beneficial effect can be accomplished with pulsatile flow generated in the extracorporeal circuit. Therefore, we i...

Dear Editor, I read the article “Choroidal blood flow change in eyes with high myopia” by Yang and Koh [1] with great interest. The authors investigated pulsatile ocular blood f low and found it to be decreased in high myopia. I commend the authors for this well organized study and want to make some contributions. The eyeball is enlarged in high myopia. This enlargement provides a larger area o...