OBJECTIVE Previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for Rosa damascena (R. damascena). In the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of R. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (PTZ). MATERIALS AND METHODS The rats were divided to five groups: (1) CONTROL...

This study investigated sex differences in responding to the pentylenetetrazol (PTZ, a gamma-aminobutyric acid A antagonist) discriminative stimulus and to substitution to PTZ during ethanol withdrawal. The PTZ stimulus has served as an anxiogenic stimulus in numerous studies. Adult male and female rats were trained to discriminate PTZ (16 mg/kg i.p.) from saline in a two-lever food-reinforced ...

Pentylenetetrazole (PTZ) is a common convulsant agent used in animal models to investigate the mechanisms of seizures. Although adult zebrafish have been recently used to study epileptic seizures, a thorough characterization of the PTZ-induced seizures in this animal model is missing. The goal of this study was to perform a detailed temporal behavior profile characterization of PTZ-induced seiz...

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABA(A) receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific ...

Piperacillin-tazobactam (PTZ) is frequently used as empirical and targeted therapy for Gram-negative sepsis. Time-dependent killing properties of PTZ support the use of extended-infusion (EI) dosing; however, studies have shown inconsistent benefits of EI PTZ treatment on clinical outcomes. We performed a retrospective cohort study of adult patients who received EI PTZ treatment and historical ...

We have designed and synthesized a pair of highly asymmetric D-aA-D′ type pyridyl-sulfonyl based isomers comprising phenothiazine (PTZ) carbazole (Cz) donor units, which are able to emit thermally activated delayed fluorescence. PTZ-pS4-Py-2Cz PTZ-mS4-Py-2Cz both possess spatial separation HOMO/LUMO on the acceptor moieties, resulting in small calculated singlet–triplet energy gaps (~0.25 eV). ...

Aim: The current study investigated the effects of artemisinin on heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), peroxidase (GSH-Px) levels were evaluated both homogenates.Material Method: Swiss albino male mice (n=42) used experiment. Animals divide...

Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvul- sive action. Valeriana officinalis (VAL) was previously believed antiepileptic, but today as sedative sleep regulator. Seizures may associated abnormal electrocardio- graphic changes cardiac dysfunction arising from epilepsy related neuronal nitric (nNO). This study aimed investigate the effects of synthas...

Thyme with the scientific moniker of Thymus vulgaris has been used in traditional medicine for treatment respiratory and gastrointestinal disease. Its extract also adopted to treat epilepsy other central nervous system (CNS) disorders. To evaluate effect T. (TVE), experimental model memory impairment caused by seizures was performed rats. Seizures Wistar rats (200-250 g) were induced a challeng...

We have investigated excited-state electron transfer in a donor-bridge-acceptor complex containing phenothiazine (PTZ) linked via tris(meta-phenylene-ethynylene) to a tricarbonyl(bipyridine)(pyridine)Re(I) unit. Time-resolved luminescence experiments reveal two excited-state (*Re) decay regimes, a multiexponential component with a mean lifetime of 2.7 ns and a longer monoexponential component o...