BACKGROUND Patients with proteinuria may suffer from substantial losses of functional proteins such as hormones and hormone-binding proteins. A limited number of studies have reported urinary losses of thyroid hormones and thyroxin-binding globulin. Overt hypothyroidism attributable to these urinary losses has been described. However, the impact of proteinuria on thyroid function parameters has...

Vascular endothelial growth factor (VEGF)-A, a major regulator for angiogenesis, binds and activates two tyrosine kinase receptors, VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1). These receptors regulate physiological as well as pathological angiogenesis. VEGFR2 has strong tyrosine kinase activity, and transduces the major signals for angiogenesis. However, unlike other representative tyrosine kinase r...

Background: Diabetic nephropathy in patients on insulin is characterized by glucose-induced inhibition of matrix-degrading enzymes is believed to contribute the matrix accumulation. Study Design: Study tried to find out the renal tubular proteins that may detect earlier phase of renal complication in diabetes. Material and Methods: 42 female patients and 27 male patients using insulin (18-20 un...

Objective: The aim of the present study was to investigate the renal protective effect of Adenanthera pavonina (A. pavonina) seed aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The renal protective effect of A. pavonina seed aqueous extract (APSAE) was studied in STZ-induced diabetic rats. APSAE (50, 100 and 200 mg/kg per day) was given daily to ...

OBJECTIVES Rutin, a polyphenolic flavonoid, was reported to have beneficial effect on drug induced nephropathy. The present study aimed to introduce 5/6 nephrectomized rat model to further evaluate its renal protective effect. METHODS Adult Wistar rats were induced to develop chronic renal failure through 5/6 nephrectomy (5/6 Nx). After that, animals were treated orally with saline, rutin at ...

BACKGROUND Mycophenolate mofetil (MMF) has long been used to manage lupus nephritis. Despite research on its long-term efficacy, it is still warranted to conduct further investigation regarding its indications, safety and outcome. This study was intended to evaluate our proposed protocol in maintenance therapy with MMF. Twenty-four lupus nephritis patients were registered prior to their receivi...

BACKGROUND It has previously been reported that patients with systemic lupus erythematosus (SLE) and glomerulonephritis do not have anti- (deoxyribonucleic acid) DNA antibodies in their urine. This finding was attributed to specific entrapment of anti-DNA antibodies by the immune complexes in the glomerular capillary walls. METHODS This phenomenon has been re-investigated as part of a study o...

Background: Patients with proteinuria may suffer from substantial losses of functional proteins such as hormones and hormone-binding proteins. A limited number of studies have reported urinary losses of thyroid hormones and thyroxin-binding globulin. overt hypothyroidism attributable to these urinary losses has been described. However, the impact of proteinuria on thyroid function parameters ha...

Yousef et al. [1] report the rejuvenation of myogenesis and neurogenesis in old mice ―24 months old, analogous to 80 year old humans ― by reversing TGF-β1/ pSmad signaling to the lower levels found in young mice. They suggest that the higher levels inhibit the capacity of stem cells in old muscle and in the hippocampus of the aged brain to contribute to differentiated tissue. Reversal was accom...

For many years, atrial fibrillation (AF) was viewed as a relatively benign dysrhythmia. However, AF is now recognized as a dangerous pathology and a major cause of potentially preventable death and disability. AF is the most common cardiac arrhythmia. It affects 3% of our population, predicted to rise to 4.5% by 2040, and affects up to 20% of over 80 year old men. 1 AF is a leading cause of str...