Purpose: To investigate the mode of action active ingredients Panax ginseng against ovarian cancer protein targets elucidated using a network pharmacology approach and molecular docking study. Methods: An integrated protein-protein interactions (PPI) targeting P. was constructed carried out for constituents target ginseng. Results: Ninety-six compounds were used simulation five different protei...

Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO dat...

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in fragment-based deconstruction reconstruction (FBDR) study tes...

Protein-protein interactions (PPI) are involved in a myriad of cellular processes, and their deregulation can lead to many diseases. One such process is protein ubiquitination that requires an orchestrated action three key enzymes add ubiquitin moieties substrate proteins. Importantly, this reversible through deubiquitinating enzymes. Both deubiquitination require PPIs once classified be utiliz...

Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO dat...

background alcoholic hepatitis (ah) is an acute manifestation of alcoholic liver disease with high mortality rates. objectives our aim was to study the molecular mechanisms of ah. materials and methods the differentially expressed genes (degs) in liver between ah and control cases were identified by analyzing the gse28619 microarray data using t-test. the kyoto encyclopedia of genes and genomes...

Defining protein complexes by analysing the protein–protein interaction (PPI) networks is a crucial task in understanding principles of biological cell. In last few decades, researchers have proposed numerous methods to explore topological structure PPI network detect dense complexes. this paper, overlapping with different densities are predicted within an acceptable execution time using seed e...

We study the correlation between codon usage bias of genetic sequences and network features protein-protein interaction (PPI) in bacterial species. use PCA techniques space indices to show that genes with similar patterns have a significantly higher probability their encoded proteins are functionally connected interacting. Importantly, this signal emerges when multiple aspects taken into accoun...

BACKGROUND Understanding protein complexes is important for understanding the science of cellular organization and function. Many computational methods have been developed to identify protein complexes from experimentally obtained protein-protein interaction (PPI) networks. However, interaction information obtained experimentally can be unreliable and incomplete. Reconstructing these PPI networ...

Proteins are complex organic compounds made up of smaller units called amino acids that bonded together in long chains. Protein interacts with other proteins or molecules and becomes essential the structure, function, regulation organisms' cells. The Protein-Protein Interaction (PPI) results a considerably large network. Consequently, there is need to find method simplify network for easy inter...