The calcium-dependent serine endoproteases prohormone convertase 1/3 (PC1/3) and prohormone convertase 2 (PC2) play important roles in the homeostatic regulation of blood glucose levels, hence implicated in diabetes mellitus. Specifically, the absence of PC2 has been associated with chronic hypoglycemia. Since there is a reasonably good conservation of the catalytic domain between species trans...

Polyphenols, a class of natural products, have been shown to exhibit cancer protective properties. Proprotein convertases form a family of mammalian subtilisin-like serine endoproteases. Increased expression of these enzymes has been associated with numerous pathologies including cancer. It has been suggested that the cancer protective effect of polyphenols might be related to their proprotein ...

RATIONALE Atherosclerosis can be achieved in animals by germline genetic engineering, leading to hypercholesterolemia, but such models are constrained to few species and strains, and they are difficult to combine with other powerful techniques involving genetic manipulation or variation. OBJECTIVE To develop a method for induction of atherosclerosis without germline genetic engineering. MET...

Journal of Lipid Research Volume 51, 201

We report on selected research presented at the ACC 66th Annual Scientific Session and Expo, including sessions on proprotein convertase subtilisin/kexin type 9 inhibitors, anti-Xa anticoagulants, and a direct thrombin inhibitor.

Literature data on the pathogenesis of atherosclerosis, use statins, ezetimibe and inhibitors subtilisin / kexin type 9 proprotein convertase monoclonal antibodies (PCSK9) in prevention treatment cardiovascular diseases have been presented.Objective - to systematize current effectiveness lipid-lowering therapy diseases.Conclusion. To date, role dyslipidemia inflammation PCSK9 established.