Aim: The present investigation highlights the formulation and evaluation of matrix tablets of propranolol hydrochloride (HCl) using a natural polymer, is gum kondagogu. Materials and Methods: Wet granulation method was used for the preparation of matrix tablets of propranolol HCl using varying proportions of natural polymer as a release retardant, Avicel pH 102 as diluent, talc and magnesium st...

The present study was carried out to develop oral sustained release tablets of propranolol HCl by different ratios of drug : matrix. Tablets were prepared by direct compression technique using xanthan gum and lactose. All the formulations (tablets) were evaluated for thickness, diameter, hardness, friability, weight variation, content of active ingredient, in vitro dissolution using USP dissolu...

A co-processed excipient was prepared from Tamarind seed polysaccharide (TSP) and mannitol in using direct compression as well as wet and dry granulation. The effect of the ratio of the two components, percentage of lubricant and particle size on the properties of the prepared co-processed excipient has been investigated. Optimal physicochemical properties of the excipient, from a manufacturing...

Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Sprague-Dawley rats were treated with a continuous 0.5 mg/hr dose of propranolol H...

Aktif farmasötik bileşenlerin çevresel kalıntıları, riskler ve sağlık sorunları ile ilişkilidir. Bunların çevreye olan etkileri toplumsal bir endişe konusu haline gelmiştir. Bu çalışmada; flurbiprofen, naproksen Na, propranolol HCl, karbamazepin, azitromisin, doksisiklin klindamisin ilaç etken maddelerinin toksisiteleri Aliivibrio fischeri toksisite testi kullanılarak belirlenmiştir. deneyinde,...

Drug delivery via buccal mucosa by means of buccoadhesive formulations offer distinct advantages over peroral administration. Recently, plant gums and exudates have been screened for their use as pharmaceutical adjuvants. The aim of this study is to evaluate matrix tablets containing Plantago psyllium seed mucilage in addition to carbopol as a mucoadhesive agent, and propranolol hydrochloride a...