Dengue virus (DENV) co-circulates as four serotypes (DENV1-4). Primary infection only leads to self-limited dengue fever. But secondary infection with another serotype carries a higher risk of increased disease severity, causing life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Serotype cross-reactive antibodies facilitate DENV infection in Fc-receptor-bearing cells by ...

The formation of the flavivirus prM-E complex is an important step for the biogenesis of immature virions, which is followed by a subsequent cleavage of prM to M protein through cellular protease to result in the production and release of mature virions. In this study, the intracellular formation of the prM-E complex of Japanese encephalitis virus was investigated by baculovirus coexpression of...

Nitrogen responsiveness of three-finger millet genotypes (differing in their seed coat colour) PRM-1 (brown), PRM-701 (golden), and PRM-801 (white) grown under different nitrogen doses was determined by analyzing the growth, yield parameters and activities of nitrate reductase (NR), glutamine synthetase (GS), glutamate synthase; GOGAT, and glutamate dehydrogenase (GDH) at different developmenta...

The objective of this study was to estimate the genetic variance for within-litter variation of birth weight (BW0) using genomic (GRM) or pedigree relationship matrices (PRM) and to compare the accuracy of estimated breeding values (EBV) for within-litter variation of BW0 using GRM and PRM. The BW0 and residual variance of BW0 were modeled by the double hierarchical generalized linear model usi...

conclusions by controlling the modifiable risk factors and modality of treatment in our study, physicians can reach more effective treatment. results at the end of the study, long-term graft failure was seen in 27 (10.2%) cases. one-year and 2-year graft survival after diagnosis of cancer were 93.6% and 91.7%, respectively. the univariate analysis showed that the incidence of chronic graft loss...

background and purpose: the goal of this study is application of the proportional hazards model (ph) and accelerated failure time model (aft), with consideration weibull distribution, to determine the level of effectiveness of the factors affecting on the level of disease-free survival (dfs) of the patients with breast cancer. materials and methods: based on the retrospective descriptive studie...

results survival probabilities at different times were determined using the cox proportional hazards and a neural network with three nodes in the hidden layer; the ratios of standard errors with these two methods to the kaplan-meier method were 1.1593 and 1.0071, respectively, revealed a significant difference between cox and kaplan-meier (p < 0.05) and no significant difference between cox and...

Nitazoxanide (NTZ), a drug currently being tested in human clinical trials for efficacy against chronic cryptosporidiosis, was assessed in cell culture and in two animal models. The inhibitory activity of NTZ was compared with that of paromomycin (PRM), a drug that is partially effective against Cryptosporidium parvum. A concentration of 10 microg of NTZ/ml (32 microM) consistently reduced para...

The current methods of effort estimation frequently take indirect account of the tasks of software performance engineering (SPE), and provide widely differing conclusions. In order to create transparency and acceptance for this task that has been growing in importance for years in the context of the life cycle of IT systems, an approach (PRM Performance Risk Model) is adopted that derives resou...

BACKGROUND The envelope (E) protein of dengue virus (DENV) is the major immunogen for dengue vaccine development. At the C-terminus are two α-helices (EH1 and EH2) and two transmembrane domains (ET1 and ET2). After synthesis, E protein forms a heterodimer with the precursor membrane (prM) protein, which has been shown as a chaperone for E protein and could prevent premature fusion of E protein ...