It is the position of the American Association of Orthopaedic Medicine that prolotherapy is a safe efficacious therapy for the treatment of selected cases of low back pain and other chronic myofascial pain syndromes. This is based upon basic science data showing the effects of prolotherapy in animal models, clinical studies, a lengthy history of clinical use and efficacy, and increasingly wides...

OBJECTIVE To compare the effectiveness and cost-effectiveness of eccentric loading exercises (ELE) with prolotherapy injections used singly and in combination for painful Achilles tendinosis. DESIGN A single-blinded randomised clinical trial. The primary outcome measure was the VISA-A questionnaire with a minimum clinically important change (MCIC) of 20 points. SETTING Five Australian prima...

Objectives: This study was conducted to assess effectiveness of dextrose prolotherapy, Electromyography (EMG) Guided Botulinum Toxin – A (BTX-A) Injection, and combination between them in treatment recurrent TMJ Dislocation cases. Subjects methods: current carried out on 60 adult patients suffering from Dislocation. The divided equally into three groups, Group I: 20 were treated with EMG guided...

Hypertonic dextrose injections (prolotherapy) is an emerging treatment for symptomatic knee osteoarthritis (OA) but its efficacy is uncertain. We conducted a systematic review with meta-analysis to synthesize clinical evidence on the effect of prolotherapy for knee OA. Fifteen electronic databases were searched from their inception to September 2015. The primary outcome of interest was score ch...

BACKGROUND Increasing evidence has supported the use of dextrose prolotherapy for patients with osteoarthritis. However, the real benefits may be affected by differences in injection protocols, comparative regimens, and evaluation scales. METHODS PubMed and Scopus were searched from the earliest record until February 2016. One single-arm study and five randomized controlled trials were includ...

Objective: The objective of this selective EBM review is to determine whether or not “Is regenerative injection therapy (prolotherapy) effective at reducing pain associated with knee osteoarthritis?” Study Design: Review of all English language primary studies published in 2012 and 2013. Data Sources: One randomized control trial, one randomized crossover study and one single-arm uncontrolled s...

The Journal of the American Osteopathic Association February 2013 | Vol 113 | No. 2 122 rigor documented positive clinical outcomes from the 1930s to the early 2000s.9 Our group has conducted an openlabel trial10 and a blinded randomized controlled trial11,12 (Clinical Trial number NCT00085722) assessing prolotherapy for patients with knee OA. In the open-label trial, we compared pain and disab...

Background Osteoarthritis is a common degenerative disease. Prolotherapy is an alternative therapy used in multiple musculoskeletal disorders. Objective To compare the effectiveness of intra-articular dextrose injection versus peri-articular prolotherapy in patients with knee osteoarthritis (KOA). Methods Fifty-two adults with painful primary knee osteoarthritis for at least three months we...

INTRODUCTION The aim of this review was to identify and evaluate existing research to determine the clinical effectiveness and safety of prolotherapy injections for treatment of lower limb tendinopathy and fasciopathy. REVIEW Nine databases were searched (Medline, Science Direct, AMED, Australian Medical Index, APAIS-Health, ATSIhealth, EMBASE, Web of Science, OneSearch) without language, pub...

Introduction: De Quervain's tenosynovitis is a disease with pain in the styloid process area due to chronic inflammation of tendons covering abductor pollicis longus and extensor brevis muscles at level distal radius. This study aims describe treatment de prolotherapy.
 Case presentation: A woman, 49 years old, working as cleaning service, came hospital complaints her right thumb wrist. Pa...