Peroxisome proliferator-activated receptors are nuclear receptors that were isolated for their ability to modulate lipid metabolism. Similar to other members of the nuclear receptor family, peroxisome proliferator-activated receptors bind ligand as heterodimers and exert their effects via transcriptional regulation through their DNA binding domains. During the past decade, it has become clear t...

A peroxisome proliferator-responsive element is located in the 5'-flanking region of the gene encoding rat hydratase-dehydrogenase, the second enzyme of the peroxisomal beta-oxidation pathway. DNase I footprint analysis with nuclear extracts from proliferator-responsive rat H4IIEC3 cells revealed two protected regions within the 196-base pair peroxisome proliferator-responsive element. Both reg...

Background:Molecular biology and human medical genetics have introduced several novel biomarkers giving control over vital body functions, of these are transcriptional factors known as peroxisome proliferator activated- receptors “PPARs”. The aim this review is to shed light on available online information published research works about biomarkers. current will try display those findings mainly...

background:  we determined the blood lipid-lowering effects ofeicosapentaenoic acid (epa) on hypertriglyceridemic subjects with leu162/val in exon 5 and g/c in intron7 polymorphism of peroxisome proliferator-activated receptor alpha (pparα)genotypes that, to our knowledge, have not been previously studied. methods:  a total of170 hypertriglyceridemic subjects were enrolled and genotyped for ala...

In this study we investigated if peroxisome proliferator-activated receptor β/δ activation protects from copper-induced acute liver damage. Mice treated with copper had significant body weight loss, serum alanine aminotransferase increase, modest changes in liver histology, increase of tumor necrosis factor α and macrophage inflammatory protein 2 mRNA and 8-hydroxy-2'-deoxyguanosine. Mice treat...

BACKGROUND Systemic therapeutics targeting the peroxisome proliferator-activated receptors have been found to be beneficial in the treatment of diabetic retinopathy. In this paper, we provide a rationale for the use of these therapeutics as intraocular agents. In addition, we introduce the peroxisome proliferator-activated receptors and describe their functions in response to the drugs. DISCU...

Several decades ago, fibrates were approved for the treatment of dyslipidemia, whereas thiazolidinediones were screened in animal models to improve glucose homeostasis and were subsequently developed for the treatment of type 2 diabetes mellitus. Relatively recently, these drugs were found to act via peroxisome proliferator-activated receptors, nuclear receptors that control lipid metabolism an...

Submit Manuscript | http://medcraveonline.com J Nutr Health Food Eng 2015, 3(1): 00101 Abbreviations: UCP: Uncoupling Proteins; PGC1-α: Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha; PPARα; Peroxisome Proliferator-Activated Receptor Alpha; BAIBA: β-Aminoisobutyric Acid; ROS: Reactive Oxygen Species; FFA: Free Fatty Acids; ETC: Electron Transport Chain; ATP: Adenosine Tri...

Peroxisome proliferator-activated receptor γ plays an important role in lipid and glucose homeostasis and is the target of many drug discovery investigations because of its role in diseases such as type 2 diabetes. Activation of peroxisome proliferator-activated receptor γ by agonists leads to a conformational change in the ligand-binding domain altering the transcription of several target gene...