Therapeutic strategies targeting the programmed cell death-ligand 1/programmed cell death-1 pathway have shown significant responses and good tolerability in solid malignancies. Although preclinical studies suggest that inhibiting programmed cell death-ligand 1/programmed cell death-1 interactions might also be highly effective in hematological malignancies, remarkably few clinical trials have ...

Programmed cell death protein-1 and programmed ligand-1 pathway activation play a vital role that can be modulated by tumor cells to blunt host immune surveillance. Periphery expression level on cluster of differentiation 4+ 8+ T lymphocytes 185 female patients first diagnosed with triple negative breast cancer in Tianjin Medical University Cancer Institute Hospital were analyzed multicolor flo...

Bregs: B regulatory cells BP: bullous pemphigoid CTLA-4: cytotoxic T-lymphocyteeassociated protein 4 IRAE: immune-related adverse events PD-1: programmed cell death protein 1 PD-L1: programmed death ligand