background and aims: this research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. materials and methods: the control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. genotypes for alu insertion polymorphisms (a1/a1, a1/a2 and a2/a2) were described...

Objective Objective: Gelatinases degrade extracellular matrix (ECM) components to make physiological remodeling and contribute to pathological tissue destruction in endometriosis. It is known that gelatinases’ function is resistant to suppression by progesterone in endometriosis. The ability of progesterone to impact gene expression depends on the progesterone receptor-A/-B (PR-A/PR-B) ratio. A...

male breast cancer is a rare disease with an increasing trend. due to limited information especially about the genetic basis of the disease in iran and the lower age of its onset, the disease requires more attention. the aim of this study was to screen the male patients with breast cancer for brca mutations as well as tissue markers of estrogen receptor (er), progesterone receptor (pr), human e...

male breast cancer is a rare disease with an increasing trend. due to limited information especially about the genetic basis of the disease in iran and the lower age of its onset, the disease requires more attention. the aim of this study was to screen the male patients with breast cancer for brca mutations as well as tissue markers of estrogen receptor (er), progesterone receptor (pr), human e...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

background: progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. investigations have showed that polymorphism of progesterone receptor (pgr) is associated with some diseases. objective: to analyze the potential relationship between male infertility and the +331g/a and progins polymorphisms of pgr gene. materials and...

In previous studies, the neuroprotective effect of progestrone in diffuse traumatic brain injury has been shown. This study used mifepristone (RU-486), a potent progesterone receptor antagonist, to evaluatethe hypothesis that the neuroprotective effect of progesterone in traumatic brain injury is mediated by the progesterone receptors. The ovariectomized rats were divided into 6 groups. Brain i...

The purpose of the work – to analyze data from world literature regarding thedetermination probable role progesterone receptor gene polymorphism asa factor in occurrence premature birth.Conclusions. 1. Progesterone plays a significant inthe mechanisms development and course miscarriage, negative pregnancy outcomeand low birth weight newborns. 2. probability threat birthin different periods gest...

Background: Infertility is defined as inability to achive pregnancy after one year of unprotected regular intercourse.it has been reported that about 10-15% of young couples suffer from infertility. There is evidence that antioxidants improve the fertility rate. Prunus cerasus contains strong antioxidant activity. The aim of this study is to evaluate Prunus cerasus effects on expression of prog...