BACKGROUND Research into the etiology of breast cancer has recently focused on the role of the immunity and inflammation. The proinflammatory cytokines IL-17A and IL-17F can mediate inflammation and cancer. To evaluate the influences of IL-17A and IL-17F gene polymorphisms on the risk of sporadic breast cancer, a case-control study was conducted in Chinese Han women. METHODOLOGY AND PRINCIPAL...

Background and Aims: Recent evidence suggests that T helper (Th) 17 cells are involved in the emergence of asthma. Th17 cells have a key role in inducing inflammation in asthmatic airways thus Interleukin (IL)-17A, the main cytokine of Th17, contributes to airways inflammation. Materials and Methods: We evaluated the level of IL-17A and total immunoglobulin E (IgE) in sera of 100 asthmatic p...

sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...

}lomogenates of testes from human fetuses of 12-16 weeks gestation were incubated in vitro with pregnenolone-4-14C and pregnenolone-7-3Hsulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearin~ the tritium label only, were identified in the conjugated fraction. Progesterone, 17~-hydroxyprogesterone, 17a-hydroxypregnenolone, dehydroepiandrosterone, androstenedione and testos...

Villee et al. (1, 2) have described a diphosphopyridine nucleotide-linked isocitric dehydrogenase system in human placenta which is stimulated by estradiol-170, estrone, equilin, and equilenin. The enzyme system is stimulated to a much lesser extent by estriol, progesterone, diethylstilbestrol, testosterone, I9-nortestosterone, 17a-ethinyl estradiol, and estradiol-17a. Recently, Williams-Aschma...

The administration of spironolactone, a diuretic steroid, is known to cause a depletion of microsomal cytochrome P-450 in those tissues which have a high activity of steroid 17a-hydroxylase. In this paper, studies are presented to indicate that the sulfur atom located at the carbon 7-a position on the spironolactone molecule is required for the loss of the heme and apoproteins of adrenal or tes...

The hydrogen-bonded complexes of 17a-ethinyl-estradiol, progesterone, and testosterone with adenineand uracil-derivatives have been investigated by means of nuclear magnetic resonance (NMR) spectroscopy using deutero-chloroform as a solvent. The thermodynamic and NMR-parameters (equilibrium constant K, enthalpy AH, entropy AS, and relative chemical shift of the com­ plexes A8C) for selfassociat...

Background: Pre-eclampsia (PE) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. Imbalance in helper T cell functions may play a role in predisposing to PE or severity of the disease. Elevated frequencies of Th17 cells in the peripheral blood of PE patients have been reported. Several single nucleotide polymorphisms (SNP) within ...