Ten patients with myotonic dystrophy were allocated at random to treatment with disopyramide and procainamide in a cross-over trial. Disopyramide was found to be at least as effective as procainamide in the relief of myotonia; and two patients who could not tolerate procainamide both tolerated disopyramide.

The in vitro effect of procainamide on plasma cholinesterase (PCHE) activity in the plasma of ten normal ASA physical status I patients was studied using a kinetic method. The mean plasma cholinesterase activity without procainamide (control) was 0.90 +/- 0.09 units.ml-1. The dibucaine numbers of all the samples were in the normal range of 78 to 86, indicating normal genotypes. The mean plasma ...

The antiarrhythmic effects of procainamide and phenytoin were studied in 81 patients admitted to the coronary care unit at the University Hospital in Linköping because of a suspected or proven diagnosis of acute myocardial infarction, and who developed ventricular arrhyhmias, requiring treatment, during the first 8 hours in hospital. Patients were randomly allocated to a procainamide of phenyto...

Over the past two decades, familiarity with the clinical use of procainamide (“Pronestyl,” Squibb) has increased. The dose of this drug that is effective in suppressing ventricular arrhythmias varies widely in different patients. The extent of this variability is most notable in reports of patients who required exceptionally large doses of procainamide to control recurrent ventricular tachycard...

BACKGROUND AND OBJECTIVES It has already been proved that procainamide potentiates the neuromuscular blockade of d-tubocurarine; however, the mechanism of this potentiation is controversial. The aim of this study was to assess the influence of procainamide on the neuromuscular blockade produced by rocuronium and investigate the mechanisms of this interaction. METHODS Fifteen rats (250 to 300 ...

SUMMY A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750mg/day). The plasma concentrations of procainamide and N-acetyl procainamide were at subtherapeutic levels. Discontinuation of procainamide led to complete recovery. A bone marrow a...

BACKGROUND Intravenous amiodarone and procainamide are both used as therapies for refractory supraventricular tachycardia (SVT). However, no studies have compared the efficacy and safety of these agents in pediatric patients. METHODS AND RESULTS All patients treated with intravenous amiodarone or procainamide during 25 consecutive months for the following mechanisms of SVT were included: orth...

We measured myocardial blood flow and myocardial procainamide concentration in 24 sections of left ventricle following occlusion of the left circumflex coronary artery in 11 dogs. "C-Labeled procainamide was infused at a constant rate (40 jig/kg P r m ' n ) following completion of the coronary artery occlusion. At the end of 4 hours, the infusion was terminated and the dogs were killed. Regiona...

procainamide and N-acetylprocainamide in plasma or serum by high-performance liquid chromatography. Clin Chem 197723:7058. 10. Lai C, Kaniath BL, Look ZM, Yacobi A. Determination of procainamide and N-acetylprocainamide in biological fluids by high-pressure liquid chromatography. J Pharm Sci 1980;69:982-4. 11. Walberg CB, Wan SH. Clinical evaluation of EMIT procainamide and N-acetylprocainainid...

No previous studies have determined the pharmaco-dynamics of intravenous procainamide when administered in a dose of 15 mg/kg and at a rate of 50 mg/min, as is common practice during electropharmacologic testing. In this study, 30 patients received procainamide in this fashion; the right ventricular effective refractory period and the QRS duration at a ventricular pacing rate of 120/minute were...