For medical classification problems, it is often desirable to have a probability associated with each class. Probabilistic classifiers have received relatively little attention for small n large p classification problems despite of their importance in medical decision making. In this paper, we introduce 2 criteria for assessment of probabilistic classifiers: well-calibratedness and refinement a...

A new approach for constructing tests for association between a random right censored life time variable and a covariate is proposed. The basic idea is to first arrange the observations in increasing order of the covariate and then base the test on a certain point process defined by the observation times. Tests constructed by this approach are robust against outliers in the covariate values or ...

The least-squares probabilistic classifier (LSPC) is a computationally efficient alternative to kernel logistic regression (KLR). A key idea for the speedup is that, unlike KLR that uses maximum likelihood estimation for a log-linear model, LSPC uses least-squares estimation for a linear model. This allows us to obtain a global solution analytically in a classwise manner. In exchange for the sp...

Human activity recognition from accelerometric data (e.g., obtained by smart phones) is gathering a great deal of attention since it can be used for various purposes such as remote health-care. However, since collecting labeled data is bothersome for new users, it is desirable to utilize data obtained from existing users. In this paper, we formulate this adaptation problem as learning under cov...

Effective delivery of adaptive radiotherapy requires locating the target with high precision in real time. System latency caused by data acquisition, streaming, processing and delivery control necessitates prediction. Prediction is particularly challenging for highly mobile targets such as thoracic and abdominal tumors undergoing respiration-induced motion. The complexity of the respiratory mot...

MOTIVATION 5-methylcytosine (5mC) is a widely studied epigenetic modification of DNA. The ten-eleven translocation (TET) dioxygenases oxidize 5mC into oxidized methylcytosines (oxi-mCs): 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). DNA methylation modifications have multiple functions. For example, 5mC is shown to be associated with diseases and oxi-mC s...